摘要
探讨进驻高原不同海拔高度不同时间健康青年血清白细胞介素— 2 (IL— 2 )的活性变化。方法 :对从平原 (海拔 1 4 0 0m)进驻海拔 370 0m和 5380m高原第 7天和半年的某部 56名官兵 ,采用放射免疫法进行IL— 2测定 ,并以平原 2 8名健康青年作对照。结果 :初入海拔 5380m高原第 7天及居住半年时IL— 2活性较平原降低差异显著 (P <0 0 5或P <0 0 1 ) ;370 0m居住半年时变化无统计学差异 (P >0 0 5)。初入高原第 7天 ,海拔 5380m较 370 0mIL— 2降低差异非常显著(P <0 0 1 ) ;高原居住半年时 ,5380m较 370 0mIL— 2降低差异显著 (P <0 0 5)。进驻海拔 370 0m ,第 7天较半年IL— 2无显著性差异 (P >0 0 5) ;进驻海拔 5380m ,第7天较半年IL— 2降低差异有显著性 (P <0 0 5)。结论 :高原低氧 ,IL— 2水平降低引起免疫调节降低 ,导致免疫功能紊乱。
Object:To investigate the changes of serum Interleukin-2(IL-2) activity in different elevations at different times.Method:The levels of IL-2 were examinated by RIA in 56 healthy youths who arrived at the elevations of 3700m and 5380m after 7 days and 6 months,and 28 healthy youths inhabited in plain were used as controls.Results:The IL-2 activity levels were decreased at 5380m high elevation hypoxia environment than those in plain group after 7 days and 6 months with highly significant difference(P<0.05 or P<0.01);they were not changed at 3700m elevation after 6 months(P>0.05).The IL-2 levels were significantly decreased at 5380 elevation as compared with 3700m elevation after 7 days and 6 months (P<0.01 or P<0.05).The IL-2 levels were not changed at 3700m after 7 days compared with 6 months(P>0.05);they were significantly decreased at 5380m after 7 days compared with 6 months (P>0.05).Conclusion:In hypoxia environment of high altitude,decrease of IL-2 level leads to decreasing of immunoregulation,and result in immunologic function disturbance.
出处
《西藏医药》
2000年第3期5-6,共2页
Tibetan Medicine
基金
国家自然科学基金资助项目! (编号 :3970 190 )
关键词
高原
白细胞介素-2
放免法
High altitude,Interleukin-2,Radioimmunoassay.
