摘要
目的:评价华佗再造丸治疗缺血性脑卒中的有效性,以指导临床医生合理用药。方法:检索国内外最新华佗再造丸临床试验报告文献。2位研究者独立提取研究资料,采用Cochrane协作网提供的软件Review Manager 5.1软件进行研究资料的统计分析。结果:10篇随机对照试验满足纳入标准,共治疗942例缺血性脑卒中患者。1篇文献为4分、1篇文献为2分、5篇文献为1分。研究之间不存在异质性(χ2=3.01,df=6,P=0.81>0.05),可进行固定效应模型分析(M-H Fixed法),有效率的OR=5.67和95%CI(3.70,8.68),差异有统计学意义(P<0.000 01)。结论:华佗再造丸临床疗效Meta分析显示,华佗再造丸治疗缺血性脑卒中是有效的,且有统计学意义。
OBJECTIVE：To evaluate the efficacy of Huatuo Zaizao Pills for ischemic stroke so as to provide guidance for clinical rational drug use. METHODS： We reviewed the recent literature both at home and abroad about clinical trials on the efficacy and safety of Huatuo Zaizao Pills. The research data were retrieved by 2 review authors independently and which were analyzed statistically using Review Manager 5.1 software provided by the Cochrane Collaboration network. RESULTS： A total of l0 randomized controlled trials （RCTs） involving 942 ischemic stroke cases met the inclusion criteria, with one literature recorded as 4 points, one 2 points, five 1 point. Heterogeneity did not exist among them （X^2 =3.01 ,df=6,P =0. 81 〉0. 05） thus the fixed effect model analysis （M-H Fixed method） was available; the efficacy OR =5. 67 and 95% CI （3. 70,8. 68） showed statistically significant differences （P 〈0. 030 01 ）. CONCLUSION： The meta-analysis revealed that Huatuo Zaizao Pills is effective for cerebral ischemic stroke and the differences were of statistical significance.
出处
《中国医院用药评价与分析》
2012年第9期772-775,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
