摘要
目的:观察短期降糖治疗对冠心病并糖尿病(diabetes mellitus,DM)患者臂-踝脉搏波速度(brachio-ankle pulse wave velocity,baPWV)的影响。方法:选择冠心病并DM患者70例,在冠心病规范化治疗、生活方式干预的前提下,服用二甲双胍片和格列齐特缓释片治疗6个月,观察治疗前后血糖、血脂、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、超敏C-反应蛋白(high sensitive C-reactive protein,hs-CRP)、一氧化氮(nitric oxide,NO)、内皮素(endothelin,ET)及baPWV的变化。结果:治疗后甘油三酯、低密度脂蛋白胆固醇、空腹血糖、餐后2 h血糖、HbA1c及hs-CRP较治疗前显著下降(P<0.01),NO水平显著上升(P<0.01),ET水平及baPWV较治疗前相比无显著差异(P>0.05)。结论:冠心病并DM患者在冠心病规范化治疗、生活方式干预的前提下,短期服用二甲双胍片和格列齐特缓释片并不能逆转患者的PWV而改善动脉弹性。
Objective： To investigate the effects of brachio-ankle pulse wave velocity（baPWV） in patients with coronary artery disease and diabetes mellitus（DM） after short term antidiabetic therapy.Methods： A total of 70 DM patients with coronary artery disease were selected.Under the premise of standardized treatment and lifestyle intervention to coronary heart disease,taking metformin and gliclazide treatment for 6 months,the changes of blood glucose,blood lipid,glycosylated hemoglobin（HbA1c）,high sensitive C-reactive protein（hs-CRP）,nitric oxide（NO）,endothelin（ET） and baPWV before and after treatment were observed.Results： Levels of teriglyceride（TG）,lowd ensity lipoprotein-cholesterol（LDL-C）,fasting plasma glucose（FPG）,2 hour postprandial blood glucose（2 h PG）,HbA1c and hs-CRP are significantly decreased after than before treatments.（P0.01）,level of NO significantly increased（P0.01）,levels of ET and baPWV have no significant differences（P0.05）.Conclusion： Under the premise of standard treatment and lifestyle intervention,metformin and gliclazide treatment can not reverse PWV of DM patients with coronary artery disease after short therapy,improve elasticity of aorta.
出处
《河南医学研究》
CAS
2012年第3期299-301,共3页
Henan Medical Research
基金
郑州市科技创新领军人才项目(096SYJH33114)
关键词
降糖治疗
糖尿病
脉搏波速度
antidiabetic therapy
diabetes mellitus
pulse wave velocity
