摘要
目的探讨腹部多发伤患者引流液可溶性髓系细胞触发受体-1(sTREM-l)对腹源性脓毒症的早期诊断价值。方法采用回顾性研究方法,选择2010年2月～2011年2月发病24h内的腹部多发伤患者60例为研究组,15例择期胃大部切除术患者作为对照组。采用双抗体夹心酶标免疫分析(ELISA)法定量测定腹腔引流液sTREM-1浓度,并检测同期患者血浆sTREM-1、血浆前降钙素(PCT)、超敏C反应蛋白(CRP)作为检测指标参照,研究此类患者术后腹腔引流液sTREM-1动态变化规律,分别评价sTREM-1、CRP和PCT对腹源性脓毒症的诊断价值并做比较,同时评价sTREM-l对病人预后的预测价值。结果腹部多发伤患者引流液组sTREM-1浓度(102.298±9.63ng/ml)明显高于对照组引流液sTREM-1浓度(25.35±9.41ng/ml,P<0.01);并发脓毒症组sTREM-l浓度(102.29±89.63ng/ml)显著高于非脓毒症组(65.35±37.26ng/ml,P<0.05);腹源性脓毒症患者存活组sTREM-l浓度低于死亡组(P<0.01)。结论早期腹腔引流液sTREM-1检测对腹源性脓毒症的早期诊断具有一定价值,与外周血sTREM-1、PCT及CRP联合诊断可能更有意义,对预后的预测有较高的准确性。
Objective To explore the early diagnostic value of sTREM - 1 to abdominalderived sepsis. Methods Using retrospec- tive method, 60 patients with abdominal muhiple trauma within 24 hours form February 2010 to February 2012 were chosen as the study group,and 15 elective gastrectomy patients as the control group, sTREM - 1 concentration was measured using ELISA test. Plasma calcito- nin （PCT） and allergic c - reactive protein （CRP） were as the test index reference to evaluate the dynamic variation of sTREM - 1. Re- suits sTREM - 1 concentration of the study group was significantly higher than those in the control group （ 102.29 ± 89.63ng/ml vs 25.35±9.41ng/ml,P 〈 0.01 ）;Sepsis group sTREM -lconcentration was significantly higher than those have no sepsis （102.29 ± 89.63ng/ml vs 65.35± 37.26ng/ml,P 〈 0.05 ） ; Patients at last lived with abdominal trauma septic has lower sTREM - 1 concentration than the dieded group （P 〈 0.01 ）. Conclusion Early sTREM - 1 celiac drainage liquid test has certain value in the early diagnosis of abdominal trauma sepsis,and the combination of plasma sTREM - 1, PCT and CRP may be more meaningful to forecast, the prognosis.
出处
《医学研究杂志》
2012年第9期96-99,共4页
Journal of Medical Research
基金
绍兴市社会发展重点科研项目(2010A33009)
