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血清抗survivin抗体与肿瘤关系的研究进展 被引量：1

Research Advance in Relationship between Serum Anti-Survivin Antibody and Tumor
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摘要 Survivin是凋亡抑制蛋白家族的新成员。抗survivin抗体作为一种血清学标志物,在大多数肿瘤和部分癌前病变患者血清中高表达,可能与免疫系统的生物学放大效应有关。在不同的肿瘤中,抗survivin抗体的表达水平有差异。一次检测若干种标志物有助于提高标志物检测的灵敏性,而特异性却没有明显的下降,提示联合检测在肿瘤的早期诊断、治疗以及判断复发方面有良好的应用前景。 Survivinis a new inhibitor of apoptosis（ IAP）pretein. As a serologic tumor marker,anti-survivin antibody has been detected in the sera of patients with common cancers and some precancerous changes ,which is probably related to the very efficient biological amplification of immune system performs. The expression level of anti-survivin antibody in different cancers is not identical. Measuring several biomarkers at one time can sub- stantially increase the sensitivity without significant decrease in specificity,indicating the considerable potential of this combined method of testing for the early diagnosis.therapy and predicting recurrence.
作者 冯明亮 周建荣
机构地区 重庆医科大学附属第一医院耳鼻咽喉科
出处 《医学综述》 2012年第17期2780-2782,共3页 Medical Recapitulate
基金 重庆市医学科研计划项目(2010-2-098)
关键词 抗survivin抗体 凋亡抑制蛋白 早期诊断 血清 肿瘤 Anti-survivin antibody Inhibitor of apoptosis Early diagnosis Serum Tumor
分类号 R739.65 [医药卫生—肿瘤]
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参考文献30

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二级参考文献3

共引文献5

同被引文献11

  • 1张思维,陈万青,孔灵芝,李连弟,鲁凤珠,李光琳,孟佳,赵平.中国部分市县1998～2002年恶性肿瘤的发病与死亡[J].中国肿瘤,2006,15(7):430-448. 被引量：171
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  • 7Tamm I, Wang Y, Sausville E, et al. IAP-family protein Survivin inhibits caspase activity and apoptosis induced by Fas ( CD95 ), Bax,caspases, and anticancer drugs [J]. Cancer Res, 1998,58 (23) : 5315 -5320.
  • 8Rohayem J, Diestelkoetter P,Weigle B,et al. Antibody response to the tumor-associated inhibitor of apoptosis protein Survivin in cancer patients[J]. Cancer Res,2000,60(7) :1815 - 1817.
  • 9Hsiao HL, Wang WS, Chen PM. et al. Overexpression of thymosin beta-A renders SW480 colon careinoma cells more resistant to ap- optosis triggered by Fasl and two topoisomerase Ⅱ inhibitors via downregulation Fas and upregulation Survivin expression. Respectively [ J ]. Careinogenesis ,2006,27 (5) :936 - 944.
  • 10苏晋捷,曾祥福,刘晓平,冯起放.凋亡抑制蛋白survivin在胃癌组织中的表达及意义[J].实用医学杂志,2010,26(8):1345-1347. 被引量：12

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医学综述
2012年 第17期

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