摘要
目的探讨前额叶、海马和扣带回后部氢质子磁共振波谱(1H-MRS)在轻度认知功能损害(MCI)和阿尔茨海默病(AD)早期诊断中的作用。方法运用氢质子磁共振波谱(1H-MRS)技术检测30例AD患者(AD组),30例MCI患者(MCI组)及30名健康老年人(正常对照组)大脑前额叶、海马和扣带回后部的各种代谢物水平。对N-乙酰天门冬氨酸(NAA)、胆碱复合物(Cho)、肌酸复合物(Cr)和肌醇(mI)波谱数据进行分析统计。结果在海马区和扣带回后部AD组和MCI组与正常对照组相比,NAA/mI降低,mI/Cr升高(均P<0.05);在前额叶AD组和MCI组与正常对照组相比NAA/mI降低(均P<0.05)。在这三个脑区,AD组的NAA/mI均显著低于MCI组(P<0.05)。在正常、MCI和AD三组中随病情进展,海马和扣带回后部NAA/mI呈递减趋势,mI/Cr呈递增趋势(均P<0.05)。AD组与正常对照组的NAA/mI差值海马部显著大于扣带回后部和前额叶;MCI组与正常对照组的NAA/mI差值海马部显著小于扣带回后部和前额叶。结论 MRS对于诊断MCI和AD有重要的意义,不同脑区NAA/mI比值是关键的诊断指标。
Objective To evaluate the role of 1H-MRS changes in the hippocampus and the posterior cingulated gyrus in the diagnosis of mild cognitive impairment（MCI） and early Alzheimer＇ s disease（AD）. Methods 1H-MRS was performed to examine the levels of N-acetyl aspartic acid （ NAA）, choline （ Cho）, creatine （ Cr）, myoinositol （mI） in the frontal lobe, the posterior cingnlated gyrus and the hippocampus in 30 cases of AD, 30 cases of MCI, and 30 cases of age-matched healthy controls. Results Compared with normal group, NAA/mI was significantly decreased and mI/Cr was significantly enhanced in hippocampus and posterior cingulated gyrus in AD and MCI groups（ P 〈 0.05 ）. In frontal lobe, NAA/mI was significantly decreased compared with normal group. In these three brain are- as, NAA/mI in AD group was significantly lower than in MCI group （P 〈 0.05）. With the disease developing from the normal, MCI to AD, mI/Cr gradually increased and NAA/mI gradually decreased （P 〈 0.05 ）. The difference of NAA/ml between AD patients and con- trois was significantly larger in the hippocampus than those in the posterior cingulated gyrus and the frontal lobe,while the difference of NAA/mI between MCI patients and controls was significantly smaller in the hippocampus than those in the posterior cingulated gyrus and the frontal lobe. Conclusion MRS is a very good method in the diagnosis of MCI and AD. NAA/mI ratio in different brain regions is an important index for detecting AD and MCI.
出处
《山西医科大学学报》
CAS
2012年第9期679-683,共5页
Journal of Shanxi Medical University
关键词
轻度认知功能损害
阿尔茨海默病
磁共振波谱
mild cognitive impairment
Alzheimer＇ s disease
magnetic resonance spectroscopy
