期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

p53上调凋亡调控因子在肿瘤中的作用及其在口腔癌研究中的新进展 被引量：2

暂未订购
导出
摘要 p53上调凋亡调控因子(p53 up-regulated modulator of apoptosis,PUMA)是新发现的具有强大促凋亡作用的蛋白家族成员,可抑制肿瘤的发生并且诱导肿瘤细胞的凋亡,是非常有前景的肿瘤基因治疗靶点。本文就PUMA与肿瘤发生发展的关系进行综述,并对其在口腔癌研究中的新进展做一相关介绍。
作者 江方方 余东升
机构地区 中山大学光华口腔医学院.附属口腔医院口腔颌面外科
出处 《广东牙病防治》 2012年第9期498-501,共4页 Journal of Dental Prevention and Treatment
基金 国家自然科学基金(30973340) 广东省自然科学基金(s2011020003247和9151008901000187) 广东省科技计划国际合作项目(c1111420600091)
关键词 PUMA 抑制肿瘤 口腔癌 凋亡 基因 p53 基因 肿瘤抑制 口腔肿瘤 细胞凋亡
分类号 R739.8 [医药卫生—肿瘤]
  • 相关文献

参考文献29

  • 1Yu J, Zhang L, Hwang PM, et al. PUMA induces the rapid apopto- sis of colorectal cancer cells. Mol Cell, 2001,7 ( 3 ) :673-682.
  • 2Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is in- duced by p53. Mol Cell, 2001,7(3) :683-694.
  • 3Yu J, Wang ZH, Kinzler KW, et al. PUMA mediates the apoptotic response to p53 in colorectal cancer cells. PNAS, 2003,100 ( 4 ) : 1931-1936.
  • 4Adams JM, Cory S. Life-or-death decisions by the Bcl-2 protein fam- ily. Temds Biochem Sci, 2001,26( 1 ) :61-66.
  • 5Kelekar A, Thompson CB. Bcl-2 family proteins : the role of the BH3 domain in apoptosis. Trends Cell Biol, 1998,8(8) :324-330.
  • 6Garrison SP, Phillips DC, Jeffers JR, et al. Genetically defining the mechanism of PUMA and Bim-induced apoptosis. Cell Death differ, 2011,19(4) :642-649.
  • 7Kim MR, Jeong EG, Chae B, et al. Pro-apoptotic PUMA and anti- apoptotic phosphor-BAD are highly expressed in colorectal carcino- mas. Dig Dis Sci, 2007,52(10) :2751-2756.
  • 8Yu J. PUMA kills stem ceils to stall cancer. Mol Cell Pharmacol, 2009,1 (3) :112-118.
  • 9Pastor DM, John G, Pofitz LS. Synergistic effects of tumor necrosis factor alpha and interferon gamma on PUMA upregulation and apopto- sis in colorectal cancer cells. Cytokine, 2010,52 ( 1/2 ) :88.
  • 10Dirisina R, Katzman RB, Goretsky T, et al. p53 and PUMA inde- pendently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis. Gastroenterology, 2011,141 ( 3 ) : 1036-1045.

同被引文献19

  • 1Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009 [J]. CA Cancer J Clin, 2009, 59(4): 225-249.
  • 2Yu J, Zhang L, Hwang PM, et al. PUMA induces the rapid apoptosis of colorectal cancer cells [J]. Mol Cell, 2001, 7(3): 673-682.
  • 3Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53 [J]. Mol Cell, 2001, 7(3): 683-694.
  • 4Kim MR, Jeong EG, Chae B, et al. Pro-apoptotic PUMA and anti-apoptotic phosphor-BAD are highly expressed in colorectal carcinomas [J]. Dig Dis Sci, 2007, 52(10): 2751-2756.
  • 5Wang R, Wang X, Li B, et al. Tumor-specific adenovirus- mediated PUMA gene transfer using the survivin promoter enhances radiosensitivity of breast cancer cells in vitro and in vivo [J]. Breast Cancer Res Treat, 2009, 117(1): 45-54.
  • 6Qiu w, Wang X, Leibowitz B, et al. PUMA-mediated apoptosis drives chemical hepatoearcinogenesis in mice [J]. Hepatology, 2011, 54(4): 1249-1258.
  • 7Max J. Cancer research. Anti-inflammatories inhibit cancer growth-but how? [J]. Science, 2001, 291(5504): 581-582.
  • 8Karst AM, Dai DL, Martinka M, et al. PUMA expression is significantly reduced in human cutaneous melanomas [J]. Oncogene, 2005, 4(6): 1111-1116.
  • 9Jansson A, Arbman C, Sun XF, et al. mRNA and protein expression of PUMA in sporadic colorectal cancer [J]. Oncol Rep,2004, 12(6): 1245-1249.
  • 10Yoo NJ, Lee JW, Jeonq EG, et al. Immunobistochemical analysis of pro-apoptotic PUMA protein and mutational analysis of PUMA gene in gastric carcinoma[J]. Dig Liver Dis, 2007, 39(3):222-227.

引证文献2

二级引证文献5

广东牙病防治
2012年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部