摘要
目的研究B型钠尿肽(BNP)与肌酸激酶MB同工酶(CK-MB)在围产期子痫前期病情评估中的作用。方法回顾性分析82例孕妇临床资料,其中健康孕妇25例(A组)、轻度子痫前期患者18例(B组),未并发肺水肿的重度子痫前期患者22例(C组),并发心力衰竭肺水肿重度子痫前期患者17例(D组),检测产前6h内(T0)及产后6h内(T1)、产后24～36h内(T2)所测BNP、CK-MB浓度,并进行统计学分析。结果在T1时C组患者的BNP、CK-MB均高于A组和B组,差异均有统计学意义(t分别=6.50、6.54、3.73、2.46,P均<0.05);而D组患者较C组更高,差异均有统计学意义(t分别=7.38、3.69,P均<0.05)。线性相关性分析显示:C、D组T1时的CK-MB与BNP之间呈正相关(r分别=0.70、0.85、P均<0.05)。在T0时,D组患者的BNP、CK-MB均高于C组,差异均有统计学意义(t分别=11.61、3.43,P均<0.05),C组患者的BNP均高于A组和B组,差异均有统计学意义(t分别=6.99、6.60,P均<0.05),但A、B、C组间的CK-MB比较,差异均无统计学意义(t分别=0.47、1.30、0.74,P均>0.05)。结论 BNP及CK-MB可用于围产期子痫前期患者的病情评估,BNP的敏感性更优于CK-MB。
Objective To explore the clinical significance of BNP and CK-MB in the diagnosis and evaluation of the preeelampsia during the perinatal period. Methods A total of 82 pregnant women were assigned to 4 groups： normal pregnant women （Group A, n=25）,mild preeclampsia （Group B, n=lS）,Severe preeclampsia （Group C, n=22）, preeclampsia complicated with heart failure and pulmonary edema （Group D, n=17）. Blood concentration of BNP and CKMB during the 6 hours before delivery （To） and 6 hours after delivery （Tl）and 24 to 36 hours after delivery （T2） were measured and analyzed. Results Levels of BNP and CK-MB of group C were higher than those of the group A and B （t= 6.50,6.54,3.73,2.46, P〈0.05） on T1,and group D were higher than group C （t=7.38,3.69,P〈0.05）.Levels of CK-MB and BNP were positive related in group C and D on Tl（r=0.70,0.85 ,P〈0.05）. Levels of BNP and CK-MB of group D were higher than that of the group C on To （t=11.61, 3.43,P〈0.05）.Level of CK-MB of group C was higher than that of the group A and B（t=6.99,6.60,P〈O.05）, and it had no statistic differences among the group A,B and C（t=0.47,1.30,0.74, P〉0.05）. Conclusions CK-MB and BNP can be used to evaluate the severity of preeclampsia during the perinatal period. BNP is more sensitive than CK-MB.
出处
《全科医学临床与教育》
2012年第5期504-506,共3页
Clinical Education of General Practice
关键词
B型钠尿肽
肌酸激酶
子痫前期
心力衰竭
brain natriuretic peptide
creatine kinase
preeclampsia
heart failure
