摘要
目的探讨唑来膦酸注射液治疗肿瘤骨转移性疼痛的临床疗效及安全性。方法将我院2009年1月—2012年1月收治的恶性肿瘤骨转移患者60例,随机分为观察组和对照组,各30例。观察组给予唑来膦酸注射液治疗;对照组给予帕米膦酸二钠注射液治疗,比较两组患者的临床效果和用药后的不良反应。结果观察组患者的疼痛缓解率为96.67%,对照组患者的疼痛缓解率为76.67%,两组比较差异有统计学意义(P<0.05);用药后两组患者均未出现严重的不良反应。结论唑来膦酸注射液治疗肿瘤骨转移性疼痛效果显著,起效快、安全可靠、不良反应小,值得临床推广应用。
Objective Explore zoledronic acid injection therapy cancer metastatic hone pain clinical effectiveness and safety. Methods From Jan 2009 to Jan 2012 Malignant tumor bone 60 cases of patients were randomly divided into observation group and control group, 30 cases each, the observation group give zoledronic acid injection treatment group give palmetto pbes- phonate two sodium for injection, compared between the two groups of patients with clinical effect and adverse effect. Results The observation group of patients with pain relief rate was 96. 67%, and the control group of patients with pain relief rate was 76. 67%, two groups was comparied, it was significant difference （P 〈0. 05）. After administration of two groups of patients had no severe adverse reaction. Conclusion Zoledronic acid injection therapy cancer metastatic bone pain effect is remarkable, and the effect were fast, safe and reliable, and less side effects, and clinical application.
出处
《实用心脑肺血管病杂志》
2012年第10期1647-1648,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
肿瘤
骨转移
疼痛
唑来膦酸注射液
Neoplasms
Bone metastasis
Pain
Zoledronic acid injection
