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尼可地尔治疗不稳定型心绞痛的临床疗效观察 被引量:5

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摘要 目的观察尼可地尔治疗不稳定型心绞痛的疗效。方法不稳定型心绞痛患者86例随机分为观察组(46例)和对照组(40例)。在给予阿司匹林、低分子肝素钙、B受体阻滞剂、降脂药等常规治疗的基础上,观察组口服尼可地尔片每次5mg,每天3次,连用4周;对照组口服硝酸异山梨酯片每次10mg,每天3次,连用4周。观察两组疗效、心绞痛、心电图变化及副作用。结果观察组疗效及心电图的总有效率为80.4%,优于对照组的60.0%,两者比较差异均有统计学意义(χ2=4.33,P<0.05)。结论尼可地尔可有效改善不稳定型心绞痛的临床症状,改善心电图,总体疗效较好。
机构地区 解放军
出处 《广东医学院学报》 2012年第4期439-441,共3页 Journal of Guangdong Medical College
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  • 1郑应海.肝素加硝酸甘油治疗不稳定型心绞痛的临床观察[J].临床和实验医学杂志,2006,5(9). 被引量:8
  • 2吕强,康俊萍,杜昕,聂绍平,张崟,韩智红,胡荣,梁金鑫,郝蓬,王苏,刘彤,刘晓慧,马长生.不同危险分层的不稳定型心绞痛及非ST段抬高心肌梗死患者的治疗现状和近期预后[J].临床心血管病杂志,2005,21(2):67-70. 被引量:12
  • 3Iwai T,Tanonaka K,Motegi K,et al.Nicorandil preserves mitochondrial function during ischemia in perfused rat heart[J].Eur J Pharmacol,2002,446(1-3):119-127.
  • 4Carreira RS,Monteiro P,Kowaltowski AJ,et al.Nicorandil protects cardiac mitochondria against permeability transition induced by ischemia-reperfusion[J].J Bioenerg Biomembr,2008,40(2):95-102.
  • 5Monassier JP.Reperfusion injury in acute myocardial infarction:from bench to cath lab.Part Ⅱ:Clinical issues and therapeutic options[J].Arch Cardiovasc Dis,2008,101(9):565-675.
  • 6Liu J,Long C,Ji B,et al.Myocardial protective effects of nicorandil,an opener of potassium channels on senile rat heart[J].Perfusion,2006,21(3):179-183.
  • 7Hai S,Takemura S,Minamiyama Y,et al.Mitochondrial K(ATP) channel opener prevents ischemia-reperfusion injury in rat liver[J].Transplant Proc,2005,37(1):428-431.
  • 8Olaf O,Michael V,Cohen DM,et al.Mitochondrial KATP channels:role in cardioprotection.Cardiovasc Res,2002,55:429.
  • 9Lawson WE, Hui JC, Lang G. Treatment benefit in the enhanced external counterpulsation consortium. Cardiology, 2000,94 ( 1 ) :31-35.
  • 10Ryden L, Standl E, Bartnic M, et al. Guideline on diabetes, prediabetes and cardiovascular disease:executive summary. The Task Force on Diabetes and Cardiovascular Disease of European Society of Cardiology (ESC) and of the Euopean Association for the Study of Diabetes(EASD). Eur Heart J,2007,28( 1 ) :88-136.

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  • 1韩雅玲,臧红云,王冬梅,荆全民,王守力,王祖禄.冠状动脉介入治疗联合心脏再同步化治疗缺血性心肌病顽固性心力衰竭[J].中华心血管病杂志,2005,33(1):17-21. 被引量:30
  • 2柯元南,陈纪林.不稳定性心绞痛和非ST段抬高心肌梗死诊断与治疗指南[J].中华心血管病杂志,2007,35(4):295-304. 被引量:2233
  • 3中华医学会心血管病学会 中华心血管病杂志编辑委员会.不稳定型心绞痛诊断和治疗建议[J].中国循环杂志,2001,6:227-229.
  • 4卫生部药政局.心血管系统药物临床研究指导原则[S].1993.
  • 5Miura T, Miki T. ATP - sensitive K + channel openers : old drugs with new clinical benefits for the heart [ J ] . CmT Vasc Pharmacol, 2003, 1: 251-258.
  • 6Goldschmidt M, Landzberg BR, Frishman WH. Nicorandil: a potassium channel opening drug for treatment (ff ischemic heart disease [J] .J Clin Pharmacol, 1996, 36:559-572.
  • 7Murry CE, Jennings RB, Reimer KA. Preconditioning with is- chemia: a delay of lethal ('ell injury in ischemic myocardium [J]. Circulation, 1986, 74 (5): 1124 -1136.
  • 8Matsubara T, Minatoquchi S, Matsuo H, et al. Three minute, but not one minute, ischemia and nicorandil have a precondition- ing effect in patients with coronary artery disease [ J ]. J Am Coil Cardiol, 2000, 35 (2): 345-351.
  • 9Sato T, Sasaki N, ORourke B, et al. Nicorandil, a potent car- dioproteetive agent, acts by opening mitochondrial ATP - de- pendent potassium channels [ J. J Am Coil Cardiol, 2000, 35 (2) : 514 -518.
  • 10Helton E, Darragh R, Francis P, et al. Metabolic as pects of myocardial disease and a role of L- carnitine in the treatment of children cardiomyopathy [ J ]. Pediatrics, 2000, 105 ( 5 ) : 1260.

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