摘要
目的:观察十全大补汤加减治疗奥沙利铂致神经毒性临床疗效。方法:将42例患者随机分为治疗组22例,对照组20例,2组患者均采用奥沙利铂联合化疗方案。治疗组在对照组化疗基础上加用十全大补方,水煎服,1剂/d,于用奥沙利铂前2天开始口服,12天为1个周期,连服2周期。化疗结束后继续观察随访6个月。结果:治疗组痊愈7例,占31.82%;有效12例,占54.55%;无效3例,占13.64%;总有效率86.36%。对照组痊愈3例,占15.00%;有效10例,占50.00%;无效7例,占35.00%;总有效率65.00%。2组总有效率比较有显著性差异(P<0.05),治疗组疗效优于对照组。结论:十全大补汤加减治疗奥沙利铂致神经毒性疗效显著。
Objective： To observe clinical efficacy of modified ShiQuan DaBuTang in treating neurotoxicity induced by oxaliplatin. Method： All 42 patients were randomly divided into 22 cases in treatment group and 20 cases in control group, both groups received oxaliplatin and chemotherapy. Treatment group were also administered with modified ShiQuan DaBuTang, one dose per day, begimiing to take two days before taking oxaliplatin, one session was twelve days, for two consecutive sessions. Six-month follow-ups were performed by the end of chemotherapy. Result： Seven cases were cured in treatment group and reached 31.82%; 12 cases were effective and accounted for 54.55%; three cases ineffective and 13.64%; total effective rate was 86.36%. Three cases were cured in control group and reached 15.00%; ten cases effective and 50.00%; seven cases ineffective and 35.00%; total effective rate was 65.00%. Comparisons of both groups indicated remarkable difference in total effective rate （P〈0.05）, and treatment group was superior to control group in curative effects. Conclusion： Modified ShiQuan DaBuTang is effective in treating neurotoxicity.
出处
《西部中医药》
2012年第9期35-36,共2页
Western Journal of Traditional Chinese Medicine
