摘要
目的探讨维生素C对131I治疗分化型甲状腺癌发生放射性口腔炎或唾液腺炎的预防作用。方法 88例分化型甲状腺癌患者随机分为A组30例、B组32例与C组26例,3组均给予131I单次剂量30mCi治疗,A组于服药后2h,B组于服药后24h开始服用维生素C片10mg/次,3次/d,连续6d,2次治疗间隔3～6个月,C组服药后不用维生素C片;比较3组放射性口腔炎或唾液腺炎发生率。结果 A,B组放射性口腔炎或唾液腺炎发生率低于C组(P<0.05);A组与B组比较差异无统计学意义(P>0.05)。结论行131I治疗分化型甲状腺癌后2h和24h给予维生素C片均可有效降低放射性口腔炎或唾液腺炎的发生率。
Objective To assess the effect of vitamin C on the prevention of radiation stomatitis and salivoadenitis in patients with differentiated thyroid cancer treated with low-dose 131I （30 mCi） irradiation. Methods A total of 88 patients with differentiated thyriod cancer were randomly divided into group A （n=30）, group B （n=32） and group C （n =26）. All patients received 131I irraduation, 30 mCi for each time. Vitamin C was administered 2 hours later in group A and 24 hours later in group B, 10 mg per time, three times a day, for totally 6 days, with an interval time of three to six months between two treatments. Vitamin C was not administrated in group C. The incidences of radiation stomatitis and salivoadenitis were compared among three groups. Results The incidences of radiation stornatitis and salivoadenitis were higher in group A and B than those in group C （P（0.05）, and there were no significant difference between group A and B （P〉0.05）. Conclusion The use of vitamin C 2 hours or 24 hours later after being treated with low-dose 131I irradiation can effectively reduce the incidences of radiation stomatitis and salivoadenitis.
出处
《中华实用诊断与治疗杂志》
2012年第10期947-948,共2页
Journal of Chinese Practical Diagnosis and Therapy
基金
四川省卫生厅自然科学基金(080233)
