摘要
本文应用电子显微技术研究7例肺癌脑转移活检组织的超微病理形态特征,其中腺癌3例,鳞癌1例,神经内分泌癌1例,肺泡细胞癌1例,另1例细胞学分类不清。电镜下肺腺癌细胞表面有疏密不一的微绒毛,胞浆内有典型的微腺腔,相邻癌细胞胞膜之间可见细胞连接;肺神经内分泌癌在胞浆内有大小不一,多少不等的核心致密的神经内分泌颗粒;肺泡细胞癌在细胞表面有微绒毛,胞浆内可见Ⅱ型肺泡上皮细胞特有的嗜锇板层体;鳞状细胞癌在相邻癌细胞膜表面可查见桥粒-张力原纤维复合体和胞浆内的张力原纤维。上述脑内转移性肺癌的电镜超微结构特征对临床病理诊断和鉴别诊断具有重要意义。
The ultrapathologic characteristics of seven cases of metastatic lung cancer in brain including three cases of pulmonary adenocarcinoma,one case of neuroendocrine carcinoma,one case of brochioalveolar carcinoma,one case of squamous cell carcinoma and one undetermined were studied by using electron microscopic technique.The result indicates that the different types of metastatic lung cancer in brain remain its original ultrastructural features.Under the electron microscope,the pulmonary adenocarcinoma showed different density of microvilli on cell surface,typical intracytoplasmic microglandular cavity and cell junctions between adjacent cell membran;the pulmonary neuroendocrine carcinoma showed dense core neuroendocrine particles in different number and size in the cytoplasm;pulmonary cell carcinoma showed microvilli on cell surface and osmiophilic lamellar bodies in the cytoplasm.These characteristic appearances have great significance in clinical pathologic diagnosis and diffrential diagnosis.
出处
《电子显微学报》
CAS
CSCD
2012年第4期350-356,共7页
Journal of Chinese Electron Microscopy Society
关键词
肺癌
脑转移
超微病理
透射电镜
lung cancer； brain metastases； ultrapathology； electron microscope
