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Flt3配体在急性髓系白血病化疗过程中的变化及意义 被引量：6

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摘要 目的通过检测FLt3配体(FL)浓度在急性髓系白血病患者化疗前后的变化情况,统计分析其与白细胞数量变化的相关性。方法对48例急性髓系白血病患者进行追踪观察,于化疗前、化疗结束后5～7 d和20～30 d取外周血2,0例健康人为正常对照,应用酶联免疫吸附技术(ELISA),检测FL在白血病初治和缓解患者化疗前后浓度的动态变化。结果在急性髓系白血病初治组患者,化疗结束后5～7 d FL浓度明显大于化疗前,且明显大于对照组FL浓度([392±55.07)pg/mL,P<0.05]。在缓解组中,3个阶段的浓度差异无统计学意义(P<0.05),但明显低于对照组FL浓度(P<0.05)。并且根据直线相关分析,FL浓度与外周血白细胞数量呈明显负相关(r=-0.464,P<0.05)。结论在急性髓系白血病化疗后,FL浓度与外周血白细胞总数有一定相关性。FL浓度一定程度上反映了患者的骨髓代偿能力。
作者 王静 化罗明 郭晓楠 徐世荣 贾存荣
机构地区 河北大学附属医院血液科 河北医科大学附属第二医院血液科 河北省血液中心
出处 《广东医学》 CAS CSCD 北大核心 2012年第17期2639-2640,共2页 Guangdong Medical Journal
关键词 FLT3配体 急性髓系白血病 造血生长因子
分类号 R733.71 [医药卫生—肿瘤]
  • 相关文献

参考文献11

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二级参考文献22

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共引文献2

同被引文献54

  • 1黄耘,王思力,于永洋,樊亚群.去甲氧柔红霉素与柔红霉素治疗老年髓系白血病疗效对比[J].中华临床医师杂志（电子版）,2011,5(17):5110-5112. 被引量：8
  • 2Zheng R, Levis M, Piloto O, et al. FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells. Blood, 2004, 103 : 267-274.
  • 3Maraskovsky E, Daro E, Roux E, et al. In vivo genera- tion of human dendritic cells subsets by Flt3 ligand. Blood, 2000, 96 : 878-884.
  • 4Mckenna HJ. Role of hematopoietic ligand in expansion Curr Opin Hematol, and regulation growth factors/rid of dendritic cells. 2001, 8:149-54.
  • 5Curti A, Fogli M, Ratta M, et al. Stem cell factor and FLT3-1igand are strictly required to sustain the long-term expansion of primitive CD34^+ DR- dendritic cell precur- sors. J Immunol, 2001, 166: 848-854.
  • 6Gammaitoni L, Bruno S, Sanavio F, et al. Ex vivo ex- pansion of human adult stem cells capable of primary and secondary hemopoietic reconstitution. Exp Hematol, 2003, 31: 261-270.
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引证文献6

二级引证文献15

广东医学
2012年 第17期

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