Slc25a15基因与机体代谢的研究进展

Research Progression of S1c25a15 and metabolism

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摘要线粒体运载家族成员Slc25a15承担着向线粒体内转运鸟氨酸的重要任务,直接调控尿素循环。Slc25a15基因的异常表达与HHH综合征直接相关,并严重影响线粒体代谢、肝脏代谢、能量代谢等。本文主要探讨Slc25a15基因表达缺陷对机体代谢的影响。 Mitochondrial carrier family （MCF） is much essential for the function of mitochondria. Slc25a15, a member of MCF, transports ornithine into mitochondria and regulates the process of urea cycle. It is reported that abnormal expression of Slc25a15 is directly associated with hyperornithinemia-hyperammonemia-homocitrullinuria syndrome （HHH syndrome）, and the expression of Slc25a15 can affect mitochondrial metabolism, liver metabolism, energy metabolism and so on. This review discusses the relationship between abnormal expression of Slc25a15 and the body metabolic disorders.

作者蓝茜吕社民李冬民

机构地区西安交通大学医学院遗传与分子生物学系

出处《国外医学（医学地理分册）》 CAS 2012年第3期209-212,共4页 Foreign Medical Sciences：Section of Medgeography

基金国家自然科学基金资助项目(No.30400249) 陕西省自然科学基金资助项目(No.2010K16-04) 2009年西安交通大学校基金资助项目(No.xjj2009079) 2010年中央高校基本科研业务费专项基金资助项目(No.xjj20100031).

关键词线粒体运载家族 Slc25a15 HHH综合征能量代谢 mitochondrial carrier-family Slc25a15 HHH syndrome energy metabolism

分类号 R181.3 [医药卫生—流行病学]

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Slc25a15基因与机体代谢的研究进展

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