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胰岛自身抗体检测及其临床应用 被引量：6

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摘要 1型糖尿病（T1DM）是由致病性T淋巴细胞介导的以胰岛B细胞进行性破坏为特征的自身免疫性疾病。自身反应性T淋巴细胞破坏胰岛p细胞，使得存在于胰岛细胞内的自身抗原释放，被B淋巴细胞识别，从而产生抗体。
作者 张青青 顾愹 杨涛
机构地区 南京医科大学第一附属医院内分泌科
出处 《广东医学》 CAS CSCD 北大核心 2012年第18期2703-2705,共3页 Guangdong Medical Journal
关键词 胰岛B细胞 抗体检测 临床应用 自身免疫性疾病 1型糖尿病 胰岛p细胞 细胞介导 细胞破坏
分类号 R587.1 [医药卫生—内分泌]
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参考文献19

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  • 8BINGLEY P J, GALE E A. Progression to type 1 diabetes in islet cell antibody - positive relatives in the European Nicotinamide Dia- betes Intervention Trial: the role of additional immune, genetic and metabolic markers of risk [ J ]. Diabetologia, 2006, 49 ( 5 ) : 881 - 890.
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同被引文献43

  • 1Grossi A, Palma A, Fierabracci A, et al. Muhiorgan autoimmunity in a Turner syndrome patient with partial monosomy 2q and trisomy 10p[ J]. Gene, 2013,515:439-443.
  • 2Bahn RS, Burch HB, Cooper DS, et al. Hyperthyroidism and other causes of thyrotoxicosis: American Thyroid Association management guidelines of the and American Association of Clinical Endocrinologists[ J]. Endoer Pract,2011,17 :456-520.
  • 3Pihoker C, Gilliam LK, Hampe CS, et al. Autoantibodies in diabetes [ J ]. Diabetes,2005,54 Suppl2 : S52-61.
  • 4Wenzlan JM, Walter M, Gardner TJ, et al. Kinetics of the post- onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects [ J]. J Clin Endocrinol Metab, 2010, 95: 4712-4719.
  • 5Ziegler AG, Rewers M, Simell O, et al. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children [ J]. JAMA,2013,309:2473-2479.
  • 6Pescovitz MD, Greenbaum C J, Krause-Steinrauf H, et al. Rituximab, B-lymphocyte depletion, and preservation of beta-cell function[J]. N Engl J Med,2009,361:2143-2152.
  • 7Jorgensen KT, Rostgaard K, Bache I, et al. Autoimmune diseases in women with Turner' s syndrome [ J ]. Arthritis Rheum, 2010, 62:658-666.
  • 8Mortensen KH, Cleemann L, Hjerrild BE, et al. Increased prevalence of autoimmunity in Turner syndrome--influence of age [ J]. Clin Exp Immunol,2009 ,156 :205-210.
  • 9Lleo A, Moroni L, Caliari L, et al. Autoimmunity and Turner's syndrome[ J]. Autoimmun Rev, 2012,11 : A538-543.
  • 10Bakalov VK, Gutin L, Cheng CM, et al. Autoimmune disorders in women with turner syndrome and women with karyo typically normal primary ovarian insufficiency[J]. J Autoimmun,2012,38: 315-321.

引证文献6

二级引证文献15

广东医学
2012年 第18期

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