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较大剂量肝素追加在体外循环肝素耐药中的应用 被引量：1

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摘要 目的:评估以1～1.5倍剂量追加肝素在肝素耐药病例的疗效及安全性。方法:回顾分析肝素耐药病例[全血凝固时间(ACT)<480s]27例,分为肝素相对耐药A组(19例)和肝素明显耐药B组(7例),并从肝素抗凝正常患者中,随机选取对照组C组(19例)。常规体外循环(CPB)首次肝素抗凝剂量为400U/kg,肝素耐药时,第1次追加肝素量80～100U/kg,继后ACT仍小于480s者,一次性追加肝素使得前后2次追加总量达到首次剂量的1～1.5倍。监测术前、术后红细胞压积(HCT),血小板(PLT),凝血酶原时间(PT),激活部分凝血活酶时间(APTT),记录肝素、鱼精蛋白用量及ACT值变化,记录术中、术后出血量。结果:27例肝素耐药病例全部能达到转机的ACT标准。术中、术后出血量,PT、APTT等凝血指标与对照组比较无差异。结论:加倍剂量追加肝素纠正CPB肝素耐药安全、有效、利于掌握,明显缩短调整治疗时间。
作者 何雪明 潘成 何文评 许尹丽 龚珊鸿
机构地区 广西桂平市人民医院麻醉科
出处 《广西医科大学学报》 CAS 2012年第4期592-594,共3页 Journal of Guangxi Medical University
关键词 肝素耐药 体外循环 抗凝
分类号 R969 [医药卫生—药理学]
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参考文献11

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广西医科大学学报
2012年 第4期

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