摘要
目的:评价芒硝辅助治疗重症急性胰腺炎的疗效。方法:计算机检索Cochrane图书馆、PUBMED、EMBASE、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)和万方数据库(Wanfang Data)中有关芒硝辅助治疗重症急性胰腺炎疗效的随机对照试验,并手工检索相关文献。检索时限均为从建库至2011年11月。由3位研究者按Cochrane Reviewers'Handbook 4.2.2推荐的方法评价纳入研究的质量和资料提取,并用RevMan 5.1软件进行Meta分析。结果:共纳入4个RCT。Meta分析表明,芒硝辅助治疗组较对照组可明显降低SAP患者的腹痛缓解时间、禁食时间、住院时间和并发症发生率,但对发热时间、病死率和中转手术率二者的差异没有统计学意义。结论:芒硝辅助治疗SAP能明显缩短患者的腹痛缓解时间、禁食时间、住院时间和降低并发症发生率,但对发热时间、病死率和中转手术率二者的差异没有统计学意义。但限于纳入研究的方法学局限性芒硝辅助治疗SAP的疗效需要开展高质量的随机对照试验来验证。
Objective ： To assess the efficacy of natrii sulfas in the adjuvant treatment of severe acute pancreatitis. Methods： Cochrane library, PUBMED, EMBASE, CNKI, CBM and Wanfang Date were searched from the date of establishment of the databases to November 2011. Randomized controlled trials （ RCTs ） of natrii sulfas in the adjuvant treatment of severe acute pancreatitis were included. A manual search of relevant journals and conference proceedings were performed too. Three independent researchers evaluated the quality of each included study according to Cochrane Reviewers＇ Handbook 4.2.2 recommend standard and then extracted data. A meta-analysis was then petformed by RevMan 5.1 software. Results ： A total of 4 studies were included into the analysis. Mete-analysis showed that compared with control patients, patients adjunctively treated with natrii sulfas had significantly faster relief of abdominal pain, shorter period of abrosia, less hospitalization stay （ days ） and lower incidence of complications of SAP. But between the two groups of patients, there was no significant difference in period of fever, the rate of hospital mortality or the rate of conversion to operation. Conclusion ： Adjunctive therapy of severe acute pancreatitis with natrii sulfas can decrease the incidence of complications and shorten the duration of abdominal pain, the period of abrosia and hospitalization stay （ days ）. However, between the two groups there was no significant difference in period of fever, the rate of hospital mortality or the rate of conversion to operate. There was no enough evidence to support the natrii sulfas＇s effectiveness present since the included trials are of poor quality. Therefore, large-scale high-quality RCTs are needed.
出处
《辽宁中医药大学学报》
CAS
2012年第10期134-138,共5页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
芒硝
重症急性胰腺炎
系统评价
natrii sulfas
severe acute pancreatitis
systematic review
