摘要
目的:调查文献报道中参附注射液的临床应用情况及不良反应。方法:以"参附注射液"为检索词,检索中国期刊全文数据库(1987年1月—2012年3月)及中国生物医学期刊引文数据库涉及参附注射液的临床应用报道并查找全文,分析纳入文献中参附注射液的不良反应、适应病证、用药剂量、疗程及溶媒等。结果:共纳入文献1 433篇,除5例严重不良反应外,均为轻度不良反应。结论:基于文献分析发现参附注射液临床应用广泛,安全性较高,但临床中在治疗病种、适用剂量、治疗疗程及不良反应报道方面存在问题与不足。
Objective： To investigate the status of clinical practices and side effects related to Shenfu injection. Method： It was searched the Chinese medical citation index （CMCI） database and China national knowledge infrastructure （CNKI） database using the word ＂Shenfu injection＂. Original clinical studies of Shenfu injection which were published from January 1 987 to March 2012 in Chinese magazines were included. Result： A total of 1 433 relevant clinical studies were identified. It was investigated and analyzed the side effects of Shenfu injection. For cases with side effects, the diseases for treatment, the medication dosage, the course, and menstrum of treatment for the side effects were evaluated. All the side effects were mild except five cases of serious adverse reaction. Conclusion： Shenfu injection has been widely used in clinical patients since it came into the market in 1987. However, there are some problems in its clinical practices, such as deficiency in selecting and expanding diseases for treatment, evaluating the dosage and treatment method. Therefore, it is imperative to evaluate drugs by literature and good clinical application after the drugs come into the market with evidencebased medicine.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2012年第18期2796-2799,共4页
China Journal of Chinese Materia Medica
基金
国家"重大新药创制"科技重大专项(2009ZX09502-030)"中药上市后评价关键技术研究"
中国中医科学院自主选题研究项目(Z0133)
关键词
参附注射液
临床应用
不良反应
Shenfu injection
clinical practice
side effect
