摘要
目的评估经尿道前列腺电切(TURP)围手术期使用索利那新对术后膀胱痉挛的防治疗效。方法 BPH患者150例。随机分为3组,每组50例。索利那新组(A组):术前1d起口服索利那新1次/d,5mg/次,至拔除导尿管后3d;托特罗定组(B组):术前1d起口服托特罗定2次/d,2mg/次,至拔除导尿管后3d;吲哚美辛组(C组):疼痛时予肛纳吲哚美辛栓25mg。观察比较3组患者经尿道前列腺电切术后膀胱痉挛发生次数、持续时间以及膀胱冲洗、冲洗液转清、留置导尿管时间等。结果 A组术后24、24～48、48～72h膀胱痉挛次数(0.86±0.08,1.80±0.14,1.06±0.13)均少于B组(1.02±0.08,2.02±0.12,1.24±0.12)和C组(1.88±0.12,2.68±0.18,2.24±0.19),且与C组相比,差异有统计学意义(P<0.05)。A组术后24、24～48、48～72h膀胱痉挛平均持续时间[(0.74±0.25)、(0.17±0.03)、(0.18±0.04)h]均少于B组[(0.61±0.25)、(0.16±0.34)、(0.17±0.32)h]和C组[(0.43±0.22)、(0.13±0.04)、(0.14±0.04)h],且与C组相比,差异有统计学意义(P<0.05)。术后A组膀胱冲洗时间、冲洗液转清时间、留置导尿管时间[(2.2±0.6)、(1.6±0.6)、(5.0±0.7)d]也均早于B组[(2.3±0.6)、(1.8±0.5)、(5.2±0.8)d]和C组[(2.6±0.7)、(2.1±0.7)、(5.4±0.6)d],且与C组相比,差异有统计学意义(P<0.05)。A组总的不良反应率和口干的发生率(10.0%,6.0%)均较B组(26.0%,20.0%)低,且差异有统计学意义(P<0.05)。结论 TURP患者围手术期应用索利那新可有效防治膀胱痉挛,临床效果满意、安全。
Objective To evaluate the clinical therapeutic effect of Solifenacin in controlling bladder spasm after transurcthral resection of the prostate （TURP）. Methods 150 patients with benign prostate hyperplasia （BPH） were randomly divided into 3 groups of 50 cases. Group A was treated with Solifenacin （5 mg,QD） and group B with Tolterodine （2 mg,BID） from the day before surgery to 3 days after removal of the catheter. Group C was administered Indometacin suppositories in anus when patients felt pain. We observed and compared the frequency and duration of bladder spasm, the time of bladder irrigation,time needed for washing solution to turn clcar,and the time of catheter indwelling in the 3 groups. Results During the 24 h,24;48 h and 48-72 h after operation,the frequency of bladder spasm in group A was 0.86 ± 0.08,1.80 ± 0. 14 and 1. 06 ±0. 13,1css than that of group B （1.02 ± 0.08,2.02 ± 0. 12,1.24 ± 0. 12） and group C （1.88 ± 0. 12,2.68 ± 0. 18, 2.24± 0. 19） ,with statistically significant differences （P;0.05）. The duration of bladder spasm in group A was （0.74 ± 0.25）,（0. 17 ± 0.03） and （0. 18 ± 0.04） h,less than that of group B （0.61 ± 0.25）, （0. 16 ± 0.34） and （0. 17 ± 0.32） h and groupC （0.43± 0.22）,（0.13± 0.04） and （0.14 ± 0.04） h,with statistically significant differences （P;.0.05）. Thc timc of bladder irrigation, time needed for washing solution to turn clear and time of catheter indwelling in group A wcrc （2.2 ± 0.6）,（1.6 ± 0.6） and （5.0± 0.7） d,shorter than those of group B （2.3 ± 0.6）,（1.8 ± 0.5）,（5.2 ± 0.8） d and group C （2.6 ± 0.7）, （2. 1 ± 0.7 ）, （5.4± 0.6） d, with statistically significant diffcrences （P〈;0.05）. The ratc of total side effects and dry mouth incidence in group A were 10.0%; and 6.0%,lower than those in group B （26.0%,20. 0%）,and thc diffcrcnccs were statistically significant（P〈0.05）. Conclusions The proper use of Solifenacin during perioperative period is cffectivc for the prevention and treatment of bladder spasm following TURP procedure.
出处
《现代泌尿外科杂志》
CAS
2012年第5期446-449,共4页
Journal of Modern Urology
基金
南京市卫生青年人才培养工程项目(宁卫科字[2011]32号)
关键词
索利那新
膀胱痉挛
经尿道前列腺电切
Solifcnacin
bladder spasm
transurcthral resection of the prostate
