摘要
目的探讨抗环瓜氨酸肽抗体（抗CCP）、抗角蛋白抗体（AKA）及类风湿因子（RF）三个指标单项及联合检测对类风湿关节炎（RA）的诊断价值。方法抗CCP采用电化学发光法定量检测，RF采用速率散射免疫比浊法检测法，AKA采用免疫荧光法。结果RA组单项指标中敏感性为RF〉抗CCP〉AKA，特异性为抗CCP〉AKA〉RF，联合检测指标抗CCP＋AKA、抗CCP＋RF、AKA4-RF阳性时特异性分别提高到99．2％、96．9％、94．7％，阳性预测值为98．3％、94．6％、92．3％，抗CCP-4-AKA＋RF三项指标均阳性时，特异性、阴性和阳性预测值均为100％。结论抗CCP、AKA和RF联合检测比单项指标具有更高的特异性和阴阳性预测值，可进一步提高对RA的早期诊断率，尤其是对临床症状不典型的早期RA患者意义更大。
Objective To study the diagnostic values of anti-CCP, AKA and RF on rheumatoid arthritis（RA）. Methods Anti-CCP, AKA and RF levels were measured by different means, such as ECLIA, the rate scatting immunity method, and immunity fluorescence technique. Results The sensitivity of RF was the best, and the specificity of anti-CCP was the best. Indicator of combined dection of anti-CCP ＋ AKA, CCP ＋ RF, AKA ＋ RF, when they were positive, specificity was increased to 99.2%, 96.9% ,94. 7% ,positive predicitive value was 98.3% ,94.6% ,92.3%. Three indicator of anti-CCP ＋ AKA ＋ RF, specificity, negative and positive predictive value were 100%. Conclusions Combined detection of anti-CCP, AKA and RF has a higher specificity and predictive value of yin and yang nature than the single index and can further improve the incidence of early diagnosis of RA, especially in patients with atypical clinical symptoms.
出处
《中国实用医刊》
2012年第20期40-41,共2页
Chinese Journal of Practical Medicine
关键词
抗环瓜氨酸肽抗体
抗角蛋白抗体
类风湿因子
类风湿关节炎
Anti-cyclic citrullinuria peptide antibody
Anti-RA keratin antibody
Rheumatoid factor
Rheumatoid arthritis
