摘要
以异佛尔酮二异氰酸酯(IPDI)、聚乙二醇(PEG)、聚氧化丙烯二醇(PPG)等为主要原料,合成NCO封端的阴离子型聚氨酯(PU)预聚体,经过三乙胺(TEA)中和成盐后与丝素蛋白(SF)水溶液混合,制备出具有交联结构的丝素蛋白/聚氨酯(SF/PU)水凝胶。全反射红外光谱法(ATR)表征了SF/PU水凝胶的结构;扫描电子显微镜(SEM)观察了SF/PU水凝胶的断面形态,显示出SF/PU水凝胶具有多孔结构;紫外分光光度计法研究了SF/PU水凝胶对氯霉素和环丙沙星两种药物的释药性能,药物释放时间在10h以上;抑菌圈实验表明载药后的水凝胶对大肠杆菌的生长具有抑制作用。
A series of polyurethane（PU） prepolymers were synthesized using polyethylene isophorone diisocyanate （IPDI） ,glycol（PEG-2000）,polypropylene glycol（PPG-2000） as the main materials. After ionized by triethylamine（TEA）, the PU polymers were mixed with silk fibroin（SF） aqueous solutions, thus SF/PU hydrogeis were prepared. The micro- structure and porous morphology of SF/PU hydrogels were investigated using total reflection infrared spectrometry（ATR） and scanning electron mieroscope（SEM）. Release property of SF/PU on chloramphenicol and ciprofloxacin were tested by ultraviolet spectrophotometer（UV） and inhibitory action of drug-loaded SF/PU hydrogels on growth of escherichia coli were investigated. The results showed that the SF/PU hydrogels had a more than 10h drug release time with a porous structure.
出处
《化工新型材料》
CAS
CSCD
北大核心
2012年第9期50-52,55,共4页
New Chemical Materials
关键词
丝素蛋白
聚氨酯
水凝胶
载药
释药
silk fibroin,polyurethane,hydrogel,drug-loading,drug-release
