摘要
糖尿病是严重危害人类健康的一类疾病，注射胰岛素和胰岛移植虽能用于治疗糖尿病，但都存在一定的局限性。大量研究表明，间充质干细胞（mesenchymal stem cell，MSC）可以在化学以及生物因子的作用下，或通过基因转染的方式在体外被诱导分化为胰岛素分泌细胞，且移植后对糖尿病鼠模型有一定降血糖效果，因而成为糖尿病治疗领域的研究热点。文章综述了不同来源的MSC诱导分化为胰岛分泌细胞（insulin—producing cells，IPC）的方法及诱导分化后用于治疗1型糖尿病的研究进展。
Recently, diabetes has been one of the most severe diseases which is threatening to human health. Though hyperglycemia can be effectively reversed by injection of insulin or transplan- tation of islet, these methods have been greatly restricted by several reasons. A body of literatures have demonstrated that MSC can be differentiated into insulin-producing cells in vitro by chemical and biological substance or gene transfection, and the hyperglycemia model of mice with diabetes can be reversed through transplatation. A review on how the insulin-producing cells be induced from different origins of mesenchymal stem cells and the research progress of induction and differentiation of mesenchymal stem cells for the treatment of type 1 diabetes has been described in this paper.
出处
《医学分子生物学杂志》
CAS
CSCD
2012年第3期221-225,共5页
Journal of Medical Molecular Biology
关键词
间充质干细胞
诱导分化
胰岛素分泌细胞
1型糖尿病
mesenchymal stem cell
induction and differentiation
insulin-producing cells
type 1 diabetes
