摘要
目的比较两种超排方案在大龄不孕妇女中体外受精（IVF）临床结局。方法选择200例接受体外受精-胚胎移植（IVF-ET）的35～45岁不孕患者，随机分成两组：GnRHa短方案组为A组，GnRH拮抗剂方案组为B组，观察两组在用药时间、用药量、绒毛膜促性腺激素（HCG）激发排卵日E2水平、获卵数、受精率、优质胚胎率、临床妊娠率、流产率及取消率等。结果B组HCG日E2水平及获卵数低于A组，B组的用药时间及促排卵药物剂量大于A组，但差异均无统计学意义（P〉0．05）；受精率、流产率、优胚率两组间均无差异。B组的临床妊娠率高于A组，而取消率低于A组，结果差异有统计学意义（P〈0．05）。结论尽管B组HCG日E2水平及获卵数低于A组，但并不影响大龄不孕妇女的种植率及妊娠率，GnRH拮抗剂方案组IVF临床结局优于GnRHa短方案组。
Objective To compare the influence of two different COH protocols on IVF-ET outcome for aged infertilites. Methods Two hundred aged infertile patients35-45 years old, who underwent in vitro fertilization and embryo transfer （ IVF-ET ） from May 2010 to May 2011, were randomly divided into group A （the GnRHa＋ Gn short protocol） and group B（ the GnRH ant＋ Gn protocol）. Duration of stimulation, dosage of gonadotropin, estradiol level on hCG day, number of oocytes retrieved, fertilization rate, high quality embryo obtained, clinical pregnancy rate per transfer, miscarriage rate, cancellation rate between groupA and groupB groups were comparatively analyzed. Results The level of serum estrogen（E：） on the HCG injecting day and the rmmber of oocytes retrieved of group B were all less than those of group A, The duration of stimulation, dosage of Gn of group B were higher than that of group A, but there was no statistical significance （P〉0.05）. There were no significant differences in the fertility rate, the high quality embryos rate, abortion rates between these two groups （P〉 0.05）. The clinical pregnancy rate in group B was higher than those in group A（ 35% vs 21% ）, the cancellation rate in group B was less than that in group A, there was a significant difference between two groups （P〈0.05）. Conclusion Low estradiol level on hCG day and the small number of oocytes retrieved in group B seem no effect on the implantation rate and clinical pregnancy for aged infertilies. The IVF-ET outcome using the GnRH-ant protocol is better than that using short protocol.
出处
《中国男科学杂志》
CAS
CSCD
北大核心
2012年第7期44-46,50,共4页
Chinese Journal of Andrology
基金
基金项目资助：云南省社会发展科技计划（社会事业发展专项）重点项目（2009CA019）
关键词
不育
女性
排卵诱导
infertility, female
ovulation induction
