摘要
目的:探讨载脂蛋白A1及C1在胰腺癌组织中的表达及其临床意义。方法:采用免疫组织化学法检测28例胰腺癌组织及30例癌旁正常胰腺组织中载脂蛋白A1及C1的表达,分析二者与胰腺癌患者临床特征的相关性。结果:载脂蛋白A1及C1在胰腺癌组织中的表达阳性率分别为85.7%和89.3%,均显著高于正常胰腺组织(P<0.05);进一步分析结果显示,载脂蛋白A1及C1均与胰腺癌TNM分期、分化程度、有无淋巴结转移有关,差异有统计意义(P<0.05)。结论:载脂蛋白A1及C1可能参与了与胰腺癌的发生发展。
Objective：To investigate the expression and clinical significance of apolipoproteins A1 and C1 in Human Pancreatic Carcinoma tissues. Methods： Immunohistochemistry was used to detect the expression of apolipoproteins A1 and C1 in 28 cases of pancreatic carcinoma tissues and 30 cases of adjacent normal pancreatic tissues. The relevance of both to the clinical features of patients with pancreatic carcinoma was analyzed. Results：The positive rates of apolipoproteins A1 and C1 expressions are 85.7% and 89.3% in pancreatic carcinoma, respectively, which were significantly higher than those in normal pancreatic tissues （P〈0.05）. Further analysis results are shown that apolipoproteins A1 and C1 may be closely related with pancreatic cancer TNM staging, differentiation degree,lymph node metastasis or not. The differences were statistically significan （P〈0.05）. Conclusion： Apolipoproteins A1 and C1 may be involved in progress of pancreatic carcinoma.
出处
《甘肃医药》
2012年第9期653-654,共2页
Gansu Medical Journal
关键词
载脂蛋白
胰腺癌
apolipoproteins
pancreatic carcinoma
