摘要
目的观察局部应用卡托普利对兔耳增生性瘢痕的作用。方法将12只日本大耳白兔随机分为:卡托普利组(3只);空白对照组(3只);瘢痕组(3只);正常兔耳对照组(3只)。前3组每只耳朵建立5个兔耳瘢痕,总计90个增生性瘢痕。卡托普利组于术后21天开始局部应用10mg/ml卡托普利羧甲基纤维素胶,28天取材,进行大体观察,组织学检测。结果卡托普利组兔耳增生性瘢痕的瘢痕增生指数、表皮厚度指数较瘢痕对照组分别减少了34.1%、41.5%,真皮内的胶原含量为瘢痕对照组的68.8%(P<0.05)。结论局部应用ACE抑制剂卡托普利能改善兔耳增生性瘢痕的增生。
Objective To investigate the effect of captopril on hypertrophic scars by establishing a hypertrophic scar model on the ventral side of rabbit ears. Methods 12 rabbits were divided into 4 groups （3 rabbits in each group）： group A was experimental group（lOmg/ml captopril＋ 2.5%CMC）, group B was control group 1 （2.5%CMC）, group C was control group 2, and group D was normal group. Full-thickness excisional wounds （1 cm in diameter） were made in the ears of group A, B and C （5 scars in each ear）. 90 hypertrophic scars were made totally. The scars of the A, B, C groups were used topically with drugs from 21th to 28th days after operation, and then the samples were collected on the 28th day and analyzed. Results Compared with group B and C, group A appeared flatter, softer, and lighter scars in color. The scar elevation index （SEI） and the epidermal thickness index （ETI） decreased 34.1% and 41.5% （P〈0.05）. The collagen density was also lower than that in group B and C （P〈0.05）. There were no significant differences of those criteria between group B and group C （P〉0.05）. Conclusion This study showed that topical application of captopril impregnated carboxymethyl cellulose gel reduced hypertrophic scar formation following dermal injuries in a rabbit ear.
出处
《浙江创伤外科》
2012年第4期462-464,共3页
Zhejiang Journal of Traumatic Surgery
