摘要
目的:观察活血调脂汤对冠心病经皮冠状动脉介入术(PCI)后血液流变性及血脂的调节作用。方法:将符合纳入标准的60例PCI术后患者随机分为观察组、对照组各40例。2组患者均于PCI术后给予阿司匹林肠溶片、辛伐他汀片口服:阿司匹林肠溶片100 mg/次,2次/d;辛伐他汀片,40 mg/次,2次/d。观察组加用活血调脂汤,水煎分服,250 mL/次,2次/d。2组均以治疗1个月为1个疗程,各治疗2个疗程。观察2组血液流变学及血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)的变化情况。结果:全血高、中、低切黏度,血浆黏度、红细胞压积治疗后观察组分别为(3.52±0.62),(4.33±0.54),(7.18±1.55),(1.32±0.14)mPa.s,(3 443±5.54)%;对照组分别为(3.72±0.58),(4.52±0.64),(7.41±1.23),(1.41±0.15)mPa.s,(36.78±5.68)%。两组治疗后均明显改善(P<0.05),且观察组改善优于对照组(P<0.05)。TC,TG,LDL-C,HDL-C等指标治疗后观察组为(3.61±0.41),(2.31±0.52),(3.75±0.38),(1.95±0.26)mmol.L-1,对照组分别为(3.72±0.58),(4.52±0.64),(7.41±1.23),(1.41±0.15)mmol.L-1。两组治疗后均明显改善(P<0.05),且观察组改善优于对照组(P<0.05)。结论:活血调脂汤用于冠心病PCI术后可改善血液流变性学、血脂等各项检测指标,有利于降低PCI术后再狭窄发生率。
Objective：To observe effect of Huoxue Tiaozhi Decoction on blood rheology of blood lipid regulation in coronary heart disease patients after percutaneous coronary intervention（PCI）.Method：With incorporated into standard in 60 cases of PCI patients were randomly divided into observation group and control group,40 cases in each.Two groups of patients after PCI were given aspirin enteric-coated tablets 100 mg,bid,simvastatin tablet：（40 mg,bid）.Observation group was added with Huoxue Tiaozhi Decoction,boiling water service,250 mL/bid.The 2 groups were treated for 1 month as 1 course,2 courses as the treatment.Hemorheology and serum total cholesterol（TC）,triglyceride（TG）,low density lipoprotein（LDL-C）,high density lipoprotein（HDL-C） were observed.Result：The blood high,medium,low shear viscosity,plasma viscosity,hematocrit in treatment group were（3.52±0.62）,（4.33±0.54）,（7.18±1.55）,（1.32±0.14） mPa · s,（34.43±5.54）%;the control group were（3.72±0.58）,（4.52±0.64）,（7.41±1.23）,（1.41± 0.15） mPa · s,（36.78±5.68）%.The two groups after treatment were significantly improved（P〈0.05）,and the treat ment group was better than the control group（P〈0.05）.TC,TG,LDL-C,HDL-C indexes after treatment in treatment group were（3.61±0.41）,（2.31±0.52）,（3.75±0.38）,（1.95±0.26） mmol · L-1,those in the control group were（3.72±0.58）,（4.52±0.64）,（7.41±1.23）,（1.41±0.15） mmol · L-1.The two groups after treatment were significantly improved（P〈0.05）,and the treatment group was better than the control group（P〈0.05）.Conclusion：Huoxue Tiaozhi decoction used in coronary heart disease patients after PCI can improve hemorheological paramenters,blood lipids,reduce the incidence of restenosis after PCI.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第18期281-283,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
冠心病
PCI术
活血调脂汤
血液流变学
血脂
coronary heart disease； PCI； Huoxue Tiaozhi decoction； hemorheology； blood lipid
