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影响结直肠癌手术预后因素的回顾性分析 被引量:25

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摘要 目的:探讨影响结直肠癌手术预后的因素及不同麻醉方法与术后生存率的关系。方法:回顾性分析我院1998年1月至2010年12月期间首次行结直肠癌根治术患者780例的临床及随访资料,其中完整随访共670例,对可能影响术后生存率的因素作COX回归分析,并对3种不同麻醉方法即硬膜外麻醉(E组)、全身麻醉(G组)和硬膜外复合全身麻醉(EG组)的生存率作比较分析。结果:T分期、淋巴结侵犯、麻醉方式、围术期输血、术后化疗、复发、远处转移和手术并发症是影响结直肠癌预后的独立危险因素。不同麻醉组的生存率有统计学差异(P=0.018)。G组和EG组术后生存率相比于E组的风险系数分别为0.623(95%CI0.430~0.902,P=0.012)和0.532(95%CI0.365~0.776,P=0.001),差异有统计学意义,E组生存率低于G组和EG组;EG组术后生存率相比于G组的风险系数为0.855(95%CI0.619~1.181,P=0.341),差异无统计学意义。结论:结直肠癌手术预后与T分期、淋巴结侵犯、麻醉方式、围术期输血、术后化疗、复发、远处转移和手术并发症密切相关。全身麻醉和硬膜外复合全身麻醉术后生存率均高于硬膜外麻醉,是结直肠癌患者手术的合适麻醉方法。
出处 《实用医学杂志》 CAS 北大核心 2012年第17期2912-2915,共4页 The Journal of Practical Medicine
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参考文献15

  • 1Exadaktylos A K, Buggy D J, Moriarty D C, et al. Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis [J]? Anesthesiology, 2006,105(4) :660-664.
  • 2Biki B, Maseha E, Moriarty D C, et al. Anesthetic technique for radical prostatectomy surgery affects cancer recurrence: a retrospective analysis [J]. Anesthesiology, 2008,109 (1) : 180- 187.
  • 3Lin L, Liu C, Tan H, et al. Anaesthetic technique may affect prognosis for ovarian serous adenocarcinoma: a retrospective analysis [J]. Br J Anaesth, 2011,106(6) :814-822.
  • 4Shakhar G, Ben-Eliyahu S. Potential prophylactic measures against postoperative immunosuppression : could they reduce recurrence rates in oncological patients [J] ? Ann Surg Oncol, 2003,10 ( 8 ) : 972-992.
  • 5Koda K, Saito N, oda K, et al. Natural killer cell activity and distant metastasis in rectal cancers treated surgicalIy with and without neoadjuvant chemoradiotherapy [J]. J Am Coil Surg, 2003,197(2) : 254-260.
  • 6Tsai Y C, Won S J, Lin M T, et al. Effects of morphine on immune response in rats with sciatic constriction injury [J]. Pain, 2000,88(2) : 155-160.
  • 7Shavit Y, Ben-Eliyahu S, Zeidel A, et al. Effects of fentanyl on natural killer cell activity and on resistance to tumor metastasis in rats. Dose and timing study [J]. Neuroimmunomodulation, 2004,11 (4) : 255-260.
  • 8Hansbrough F, Ramon L, Bartle E J, et al. Alteration in splenielym pbocyte snbpopnlatious and increased mortality from sepsis following anaesthesia in mice [J]. Anesthesiology, 1985, 63 (2) : 267-275.
  • 9Hatsukari t, Hitosugi N, Matsumoto I, et al. Induction of early apoptosis marker by morphine in human lung and breast carcinoma cell lines [J].Anticaneer Res, 2003,23 (3) : 2413-2417.
  • 10覃怡,利莉,陈静,谢玉波.芬太尼对人胃癌MGC-803细胞活力的影响[J].中华麻醉学杂志,2010,30(6):705-707. 被引量:6

二级参考文献20

  • 1丁汉琳,张咸伟,张传汉.芬太尼影响MCF7细胞凋亡的实验研究[J].实用医学杂志,2004,20(12):1351-1353. 被引量:16
  • 2刘志恒,高峰,田玉科.吗啡、芬太尼、曲马多对Jurkat细胞核因子κB和IL-2合成的影响[J].中国医院药学杂志,2007,27(5):579-582. 被引量:10
  • 3王凯华.人体胃低分化粘液腺癌细胞系MGC80-3的建立及其生物学特性的初步观察[J].实验生物学报,1983,16:257-257.
  • 4Biki B,Mascha E,Moriarty DC.Anesthetic technique for radical prostatectomy surgery affects cancer recurrence:a retrospective analysis.Anesthesiology,2008,109(2):180-187.
  • 5Stefano GB,Kream RM,Mantione KJ,et al.Endogenous morphine/nitric oxide-coupled regulation of cellular physiology and gene expression:implications for cancer biology.Semin Cancer Biol,2008,18(3):199-210.
  • 6El Mouedden M,Meert TF.The impact of the opioids fentanyl and morphine on nociception and bone destruction in a murine model of bone cancer pain.Pharmacol Biochem Behav,2007,87(1):30-40.
  • 7Koch MZ,Beckhove Ph,Winkel JA,et al.Tumor infiltrating T lymphocytes in colorectal cancer:tumor-selective activation and cytotoxic activity in situ[J].Ann Surg,2006,244(6):986-993.
  • 8Choileain NN,Redmond HP.Cell response to surgery[J].Arch Surg,2006,141(11):1132-1140.
  • 9周光炎.免疫学原理[M].第1版.上海:上海科学技术出版社,2001.191-206.
  • 10Vera VD,Baehr NC,Moshirzadeh MA,et al.Clonidine attenuated early proinflammatory response in T-cell subsets after cardiac surgery[J].Anesth Analg,2006,103(4):809-814.

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