期刊文献+

儿童Perthes病患者82例血液状态分析

Analysis of blood condition of 82 children with Perthes disease
暂未订购
导出
摘要 目的检测儿童Perthes病患者血脂代谢、凝血常规有无异常,以探讨血脂代谢和凝血功能障碍是否是Perthes病的病因。方法对82例儿童Perthes病患者(观察组)的凝血常规及血脂相关指标进行统计分析,并与120例非Perthes病患者(对照组)进行比较。结果观察组血脂指标中三酰甘油(TG)、总胆固醇(TC),高密度胆固醇(HDL-c)异常率和平均值与对照组比较均无明显差异(P>0.05);观察组活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fbg)、凝血酶原时间(PT)、国际标准化值(INR)异常率和平均值与对照组比较均无明显差异(P>0.05)。结论儿童Perthes病患者可能并不存在血脂代谢紊乱和血液的高凝低纤溶状态,血脂代谢和凝血功能障碍并不是Perthes病的病因。 Objective To discuss whether the disorder of lipid metabolism or coagulation function is the cause of children′s Perthes disease.Methods We examined the TG,TC,HDL-c,APTT,TT,Fbg,PT and INR of 82 children with Perthes disease and compared the outcomes with children in the normal group(n=120).Results There was no difference about the lipid metabolism(TG,TC,HDL-c) between the Perthes group and the control group(P〉0.05).APTT,TT,Fbg,PT and INR showed no significant differences when compared with the control group(P〉0.05).Conclusion In our study,the lipid metabolism and the coagulation function are not correlated with Perthes disease.
出处 《实用临床医药杂志》 CAS 2012年第15期151-153,共3页 Journal of Clinical Medicine in Practice
关键词 儿童 PERTHES病 血脂代谢 高凝状态 易栓假说 children Perthes disease lipid metabolism hypercoagulability thrombophilia
  • 相关文献

参考文献14

  • 1Glueck C J, Freiberg R, Tracy T, et al. Thrombophilia and hypofibrinolysis: pathophysiologies of osteonecrosis[J ]. Clin Orthop Relat Res, 1997, (334): 43.
  • 2Balasa V V, Gruppo R A, Glueck C J, et al. Legg - Calve - Perthes disease and thrombophilia[J ]. J Bone Joint Surg Am, 2004, 86-A(12): 2642.
  • 3Kenet G, Ezra E, Wientroub S, et al. Perthes' disease and the search for genetic associations: collagen mutations, Gaucher's disease and thrombophilia[J]. J Bone Joint Surg Br, 2008, 90(11): 1507.
  • 4Glueck C J, Tracy T, Wang P. Legg- Calve- Perthes dis- ease, venous and arteriai thrombi, and the factor V Leiden mutation in a four - generation kindred [ J ]. J Pediatr Or- thop, 2007, 27(7): 834.
  • 5Szepesi K, Poson E, Harsfalvi J, et al. The most severe forms of Perthes' disease associated with the homozygous Factor V Leiden mutation[J]. J Bone Joint Surg Br, 2004, 86(3) : 426.
  • 6Mehta J S, Conybeare M E, Hinves B L, et al. Protein C levels in patients with Legg - Calve - Perthes disease: is it a true deficiency[J]. J Pediatr Orthop, 2006, 26(2): 200.
  • 7Glueck C J, Freiberg R, Tracy T, et al. Thrombophilia and hypofibrinolysis: pathophysiologies of osteonecrosis[J ]. Clin Orthop Relat Res, 1997, (334) : 43.
  • 8Hresko M T, McDougall P A, Gorlin J B, et al. Prospective reevaluation of the association between thrombotic diathesis and legg - perthes disease[J]. J Bone Joint Surg Am, 2002, 84 - A(9): 1613.
  • 9Koo K H, Song H R, Ha Y C, et al. Role of thrombotie and fibrinolytic disorders in the etiology of Perthes' disease[J]. Clin Orthop Relat Res, 2002, (399) : 162.
  • 10Eldridge J, Dilley A, Austin H, et al. The role of protein C, protein S, and resistance to activated protein C in Legg- Perthes disease[J]. Pediatrics,2001, 107(6): 1329.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部