摘要
目的研究注射用哌拉西林钠/他唑巴坦钠制剂的在四种临床上常用的溶媒配伍稳定性。方法以高效液相色谱法测定配伍后哌拉西林钠/他唑巴坦钠的含量变化,并考察配伍液的外观和pH值变化。结果 20℃时0.9%氯化钠注射液作为溶媒含量下降不超过3%,其他3种溶媒中随着放置时间延长,含量下降3%～9%,在10%葡萄糖注射液中含量下降最为明显。在37℃时配伍较20℃时低约6%,各配伍溶液4h内均澄明,无沉淀及浑浊发生,也无颜色变化,pH为4.65～4.97。结论为确保临床用药安全有效,配伍溶液应放置在室温(20℃)下,一般不应超过4h,建议临床用0.9%氯化钠注射液作为哌拉西林钠/他唑巴坦钠粉针剂的首选溶媒。
Objective To study the injection of piperacillin / cilostazol tazobactam sodium formulations used in four clinical stability of solvent compatibility. Methods HPLC determination of compatibility piperacillin sodium / the cilostazol tazobactam sodium content and examine the compatibility of the appearance of the liquid and pH value, Results 20℃, 0.9% sodium chloride injection as a solvent content dropped to no more than 3%, the other three kinds of solvents with prolonged storage time, decreased by 3%-9%, 10% glucose injection decreased the most obvious. Compatibility compared to 20℃ at 37℃C for about 6%, are compatible solution within 4 hours clarity, sedimentation and turbidity, color change, pH 4.65-4.97. Conclusion To ensure the safe and effective clinical use, compatibility solution should be placed under room temperature （20℃） , should generally not exceed 4h proposed clinical use 0.9% sodium chloride injection as piperacillin sodium / tazobactam sodium powder for injection The preferred solvent.
出处
《中国医药指南》
2012年第23期31-32,共2页
Guide of China Medicine
关键词
注射用哌拉西林钠/他唑巴坦钠
高效液相色谱法
配伍稳定性
Injection Piperacillin Sodium / Tazobactam Sodium, High performance liquid chromatography
Stability of Compatibility
