摘要
G蛋白耦联受体40(GPR40)是中长链脂肪酸的特异性受体。GPR40在被激活后可以刺激胰岛β细胞分泌胰岛素,从而调节糖代谢。同时,其激动剂二十二碳六烯酸还对缺血性脑损伤有保护性作用。除胰岛β细胞外,脑组织内的锥体神经元也可以合成胰岛素。胰岛素不仅可以降低血糖,对缺血性脑损伤也有保护性作用。GPR40发挥脑保护作用很可能与中枢神经内的胰岛素密切相关。
G protein-coupled receptor 40（GPR40）is a specific receptor of long-chain fatty acids.When GPR40 is activated,it can stimulate islet β cells to secrete insulin,which regulates glucose metabolism.At the same time,the agonist docosahexaenoic acid has a protective effect on ischemic brain damage.In addition to the pancreatic β cells,pyramidal neurons within the brain tissue can synthesize insulin.Insulin not only can decrease blood sugar,but also have a protective effect on ischemic brain injury.GPR40 role of cerebral protection is likely to be closely related with the insulin within the central nervous system.
出处
《医学综述》
2012年第16期2550-2552,共3页
Medical Recapitulate
基金
天津市卫生局攻关项目(07KG3
10KG208)
