摘要
干细胞因子(stem cell factor,SCF)是Cajal间质细胞(ICC)身份识别者c-kit的配体,二者结合可启动其下游细胞信号转导途径,进而大量分泌刺激肥大细胞增生的c-Kit激酶,ICC的存活及功能亦依赖相同细胞信号转导途径,故SCF成为调控c-Kit激酶最关键的细胞因子。如果SCF被过度激活,ICC异常放电增加,接受左半结肠感觉的骶髓后联合核(DCN)电活动变化明显,故SCF过度激活是IBS特征显现的节点。研究SCF过度激活c-kit导致的ICC异常电活动在IBS中作用与机制,可以为新药开发提供新思路。
The c--Kit as the identification of ICC, its ligand-stem cell factor（ SCF） can secrete large amounts of c--kit kinase stimulate mast cells to hyperplasia. The development and survival of ICC use the same cell signal transduction path- ways; therefore, SCF is the most important cytokine to the start of c--kit kinase. Our recently studies show that when SCF excessive activated, the abnormal discharge of ICC increased, then the dorsal commissural nucleus（DCN） that control the movement of left colon produce significant changes in electric activities, which indicates SCF plays an important role in pathogenesis of IBS. From that point, In order to explore the excessive activated SCF leads to abnormal discharge of ICC in the role and pathogenesis of IBS, this study Was designed to in vivo and in vitro; using the method of morphology, elec- trophysiology, molecular biology and seropharmacology, provide new ideas for the development of new drugs.
出处
《医学与哲学（B）》
2012年第8期74-75,80,共3页
Medicine & Philosophy(B)
基金
国家自然科学基金资助项目
项目编号:30871142
