摘要
尿毒症患者血液透析时肠道一过性缺血导敛肠道通透性增高、肠道菌群移位,从而诱发体内多种病理改变,在2011年国际透析大会上,Ritz首次提出"肠肾综合征"的概念,但未给出其明确定义。本文通过综述肠肾间相互影响及经肠道途径治疗肾脏疾病,阐述了"肠肾综合征"的合理性,并确立"肠肾综合征"的概念——肠道和肾脏中一个器官发生改变时对另一个器官产生不利影响,并能互为因果引起和(或)相互加重。希望通过引入"肠肾综合征",重新审视肠道和肾脏疾病的关联性,以肠道为靶点,提高慢性肾脏病的诊疗效果。
The term of ＇ intestinal-renal syndrome＇ was proposed by Ritz in 13th International Conference on Dialysis, Advances in CKD 2011. However, Ritz didn＇t give a definition of ＇ intestinal-renal syndrome＇ and he was uncertain about its reality. To characterize the ＇ intestinal-renal syndrome＇ , this paper summarized the relationship between gut and kidney in normal and disease status, and briefly reviewed what is currently known about its treatment options.
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
北大核心
2012年第4期363-365,共3页
Chinese Journal of Nephrology,Dialysis & Transplantation
关键词
慢性肾脏病
肠肾综合征
终末期肾病
菌群
chronic kidney disease intestinal-renal syndrome end stage renal disease microbiome
