摘要
目的探讨小剂量利妥昔单抗治疗难治性免疫性血小板减少症(ITP)的临床疗效及安全性。方法 6例小剂量利妥昔单抗(RTX 100 mg/次,每周1次,连续4周)治疗的难治性ITP患者,监测治疗前后血小板计数、血清免疫球蛋白等指标变化。结果完全反应1例,有效3例,无效1例,复发1例,总有效率为66.7%,持续反应率达33.3%,未发现严重不良反应。结论小剂量RTX治疗难治性ITP有效,其作为脾切除前可供选择的替代治疗方案,值得推荐。
Objective To discuss the clinic effect of low-dose rituximab on refractory ITP.Methods 6 patients with refractory ITP were treated with low-dose rituximab（RTX 100 mg,once a week,four consecutive weeks）.Platelet counts,serum immuno globin and other index changes were observed and monitored before and after therapy.Results There was 1 case of CR,3 cases of PR,1 case of NR and 1 case of recurrence.The total effective rate was 66.7%,and the durable response rate was 33.3%,with no severe side effect.Conclusion It is feasible to adopt low-dose RTX to treat refractory ITP,and RTX is worth being recommended as an alternative therapeutic option before splenectomy.
出处
《实用药物与临床》
CAS
2012年第8期492-494,共3页
Practical Pharmacy and Clinical Remedies
