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动脉钙化的研究进展 被引量：3

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摘要 动脉钙化是一种类似骨形成的主动可调节过程,分为内膜和中膜钙化。中膜钙化常见于糖尿病、衰老、肾病等多种疾病,然而目前它的确切机制尚未阐述清楚,多种因素如基质Gla蛋、低密度脂蛋白、瘦素、脂联素、骨保护素等都影响它的进程。他汀类、二膦酸盐、钙敏感受体激动剂等制剂已经显示出良好的治疗前景。
作者 王莎 刘幼硕
机构地区 中南大学衰老与老年疾病研究所 中南大学湘雅二医院老年病科
出处 《生理科学进展》 CAS CSCD 北大核心 2012年第4期263-266,共4页 Progress in Physiological Sciences
基金 国家自然科学基金(30871191)资助课题
关键词 动脉钙化 影响因素 机制
分类号 R543 [医药卫生—心血管疾病]
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参考文献14

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  • 2Di Bartolo BA, Schoppet M, Mattar MZ, et al. Calcium and osteoprotegerin regulate IGF1 R expression to inhibit vascular calcification. Cardiovasc Res, 2011,91 : 537- 545.
  • 3许勇,杨桦,乔建瓯,李西华,严兰珍,王龙,徐国江,费俭,傅继粱,王铸钢.骨保护素(Opg)基因敲除小鼠发生高转换型骨质疏松和动脉钙化(英文)[J].生物化学与生物物理进展,2007,34(3):260-266. 被引量：26
  • 4Villa-Bellosta R, Millan A, Sorribas V. Role of calcium- phosphate deposition in vascular smooth muscle cell calcifi- cation. Am J Physiol Cell Physiol, 2011,300 : C210 - C220.
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  • 7Prosdocimo DA, Wyler SC, Romani AM, et al. Regulation of vascular smooth muscle cell calcification by extracellular pyrophosphate homeostasis: synergistic modulation by cyclic AMP and hyperphosphatemia. Am J Physiol Cell Physiol, 2010,298 : C702- C713.
  • 8Osako MK, Nakagami H, Koibuchi N, et al. Estrogen in- hibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcifica- tion. Circ Res, 2010,107 : 466 - 475.
  • 9赵立玲,王敏,袁凌青,谢辉,李辉,罗湘杭,廖二元.脂联素基因敲除小鼠血管钙化的研究[J].实用预防医学,2009,16(5):1343-1346. 被引量：4
  • 10Su X, Ao L, Shi Y, et al. Oxidized low density lipoprotein induces bone morphogenetic protein-2 in coronary artery en- dothelial cells via Toll-like receptors 2 and 4. J Biol Chem, 2011,286 : 12213 - 12220.

二级参考文献29

  • 1任维华,李西华,王芳,乔建瓯,党素英,孔辉,王龙,陆顺元,孙霞,徐国江,傅继梁,费俭,王铸钢.Adiponectin基因剔除LacZ基因敲入小鼠模型的建立[J].生物化学与生物物理进展,2006,33(9):846-853. 被引量：6
  • 2Wallin R, Wajih N, Green wood GT, et al. Arterial calcification: a review of mechanisms, animal models and the prospects for therapy [J]. Med Res Rev, 2001, 21:274- 301.
  • 3Hoshi K, Ejiri S, Ozawa H. Localizational alterations of calcium, phosphorus and calcificating - related organics such as proteoglycans and alkaline phosphatase during bone calcification [J ]. J Bone Miner Res, 2001,16:289 - 298.
  • 4Shioo A, Nishizawa Y, Jono S, et al. β- glycerohosphate calcification in cultured bovine vascular smooth muscle cells [ J ]. Arterioscler Thromb vasc Biol, 1995, 15:2003 - 2009.
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  • 8Berner HS, Lyngstadaas SP, Spahr A,et al. Adiponectin and its receptors are expressed in bone-forming cells[J]. Bone, 2004, 35: 842- 849.
  • 9Luo XH, Guo LJ, Yuan LQ, et al. Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway[J]. Exp Cell Res, 2005, 309:99- 109.
  • 10Scherer PE, Williams S, Fogliano M, et al. A novel serum protein similar to C1q, produced exclusively in adipoeytes[J]. J Biol Chem, 1995, 270: 26746- 26749.

共引文献28

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生理科学进展
2012年 第4期

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