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G蛋白激活的内向整流型钾通道4基因研究进展 被引量：3

Advances in Research on G Protein-coupled Inward Rectifier K^+ Channel Gene
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摘要 G蛋白激活的内向整流型钾通道4(GIRK4)是G蛋白偶联内向整流型钾通道家族成员之一,由KCNJ5编码,广泛分布于哺乳动物心、脑等组织器官。近年研究发现,GIRK4基因异常表达与心房纤颤相关,而且可能与肥胖、代谢综合征等众多其他临床疾病的发生、发展密切相关,阐明GIRK4基因在临床疾病中的病理生理机制对探讨一些临床疾病新的诊治思路具有重要的开拓性意义。 G protein-coupled inward rectifier K＋ channel 4 （GIRK4） is a G protein-coupled inward rectifier potassium channel family member. Encoded by the KCNJS, it is widely distributed in the mammalian heart, brain, and other tissues and organs. Recent studies have demonstrated that the abnormal expression of GIRK4 gene is associated with atrial fibrillation, and meanwhile may be closely related to obesity, metabolic syndrome, and many other clinical conditions. Further research on the role the GIRK4 gene in the pathophysi- ology of these clinical conditions will definitely facilitate their clinical diagnosis and treatment.
作者 康永安 胡燕荣 李南方
机构地区 石河子大学医学院 新疆维吾尔自治区人民医院高血压中心新疆高血压研究所
出处 《中国医学科学院学报》 CAS CSCD 北大核心 2012年第4期426-430,共5页 Acta Academiae Medicinae Sinicae
基金 新疆维吾尔自治区重点实验室“新疆高血压病研究室”开放课题(XJYS0906-2011-05)~~
关键词 G蛋白激活的内向整流型钾通道4 基因 钾通道 G protein-coupled inward rectifier K ＋ channel 4 gene potassium channel
分类号 R394.3 [医药卫生—医学遗传学]
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参考文献15

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二级参考文献63

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共引文献14

同被引文献51

  • 1王志华,初少莉,陈绍行,杜俭,陆旭辉,钱文琪,吴顺娣,郭冀珍,朱鼎良.高血压住院患者病因及危险因素分析[J].高血压杂志,2005,13(8):504-509. 被引量：83
  • 2杨建梅,郭晓蕙,董爱梅,田曙光.原发性醛固酮增多症的临床特点[J].临床荟萃,2005,20(24):1381-1384. 被引量：21
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引证文献3

二级引证文献8

中国医学科学院学报
2012年 第4期

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