摘要
目的 比较以不同给药方法使用米非司酮配合米索前列醇 (以下简称米索 )终止 10～ 16周妊娠的效果及副作用。方法 将92例孕 10～ 16周自愿药流无禁忌症的妇女随机分为放置组与口服组各 46例 ,两组均口服米非司酮 15 0 mg后 ,放置组于阴道后穹窿放置米索 60 0μg,口服组服米索 60 0μg。结果 两组流产有效率、平均流产时间及阴道出血量的差异无显著性 ( P>0 .0 5 ) ,但放置组的清宫率为 2 6.67% ,口服组的清宫率为 48.78% ,两组有显著差异 ,放置组的副作用发生率也显著低于口服组。结论 米非司酮联合阴道放置与口服米索终止 10～ 16周妊娠均安全、有效 ,且前者清宫率低、副作用轻 ,优于口服。
Objective To compare the effect and side effect of oral and vaginal administration of mifepristone combined with misoprostol for induced abortion during pregnancy of 10 th and 16 th weeks.Methods 92 pregnant women during their 10 th and 16 th weeks gestation opting to voluntary abortion were induced,who were randomly classified into vaginal and oral groups.Both groups were given mifepristone 150mg,followed by misoprostol respectively used in the posterior vaginal fornix for the vaginal group and administrated orally for the oral group.Results The rate of successful abortion,the average interval from the drug administration to abortion and the amount of intrapartum hemorrhage all showed no great difference in the two groups(P> 0.05 ).The incidence of subsequent curettage in vaginal group(26.67%) was significantly lower than that in the oral group (48.78%) ,and the side effects were less frequent in the vaginal group than in the oral group.Conclusions After administration of mifepristone,both vaginal and oral administrations of misoprostol are effective and safe,but the former is less frequent in subsequent curettage and side effects than the latter.
出处
《中国综合临床》
2000年第7期530-531,共2页
Clinical Medicine of China
关键词
米非司酮
米索前死醇
中期妊娠
终止妊娠
Mifepristone Misoprostol Second trimester pregnancy Induced abortion
