摘要
目的 研究群体反应性抗体 (PRA)在肾移植中的意义。方法 对 178例肾移植患者进行了术前、术后PRA检测。结果 肾移植术前PRA阳性患者有 2 3例 ,肾移植术后发生急性排斥反应的为 2 0例。术后PRA阳性受者 5 8例 ,发生排斥反应的有 34例。移植前后PRA阴性患者有 10 8例 ,有 8例发生排斥。在肾移植患者中所产生的抗HLA抗体的频率和与HLA抗原的分布不同。
Objective To study the role of panel reactive antibody (PRA)in renal transplantation. Methods The PRA levels in 178 patients undergoing renal transplantation were detected before and after transplantation and the relationship between PRA level and renal graft rejection was studied. Results Positive PRA was detected in 23 recipients before transplantation. Among them, 20 recipients (20/178, 7.4% ) occurred acute rejection after transplantation. While 34 recipients (34/58, 58.6% ) suffered from acute rejection in 58 recipients with positive PRA only after transplantation. Only 8 cases ( 7.4% ) had acute rejection in 108 recipients with negative PRA before and after transplantation. PRA distribution in 36 recipients with positive PRA was different from the distribution of HLA antigens. Conclusion Detection of PRA before and after renal transplantation plays a very important role in evaluating outcome of renal transplantation.
出处
《中华器官移植杂志》
CAS
CSCD
2000年第4期199-200,共2页
Chinese Journal of Organ Transplantation
基金
北京市科委资助项目!(954 023600)
关键词
肾移植
群体反应性抗体
Kidney transplantation
Panel reactive antibody
