摘要
目的探讨不同血浆脑钠素N端前体肽(NT-proBNP)水平的急性心肌梗死(AMI)患者发病后1、3、6个月的左室重构差别,从而探讨NT-proBNP的临床应用价值。方法 NT-proBNP检测试剂盒检测116例AMI患者发病后24h血浆NT-proBNP水平,并心脏多普勒随访患者发病1、3、6个月左室收缩及舒张末期直径(LVDs/d),左心室射血分数(LVEF)。结果 (1)AMI患者发病后24h血浆NT-proBNP水平[(2965.68±456.32)pg/mL]明显高于对照组[(126.26±35.38)pg/mL],差异有统计学意义(P<0.05);(2)发病1个月AMI患者NT-proBNP重度升高组左室重构指标与前两组比较差异有统计学意义(P<0.05),前两组之间比较差异无统计学意义,P>0.05;发病3、6个月不同血浆NT-proBNP水平的AMI组两两比较差异有统计学意义(P<0.05)。结论血浆NT-proBNP可以预测AMI患者远期心室重构,特别是血浆NT-proBNP>5000pg/mLAMI患者早期即出现严重的心室重构。
Objective To investigate left ventricular remodeling of different plasma N-terminal brain natriuretic peptide precursor peptide （NT-proBNP） levels in acute myocardial infarction （AMI） after onset, in one month, three months and six months, so as to explore the clinical application of NT-proBNP value. Methods Plasma NT-proBNP of the 116 patients with AMI were detected by NT-proBNP assay kit, 24 hours after the onset. Left ventricular systolic and diastolic final di- ameter （LVDs/d）, left ventricular ejection fraction （LVEF） were detected by echocardiographic after onset, in one month, three months and six months. Results （1） Plasma NT-proBNP level [（2 965.68± 456.32） pg/mL] of AMI patients 24 hours after the onset was significantly higher than the level [（126.26±35.38） pg/mL] of control group, the difference was significant （P 〈 0.05）; （2） The difference of left ventricular remodeling index, between the first two groups of patients with AMI NT-proBNP and severe elevated group after onset, in one month the difference was statistical significance （/9 〈 0.05）, how- ever between the first two groups was not statistically significant （/9 〉 0.05）; the difference of left ventricular remodeling in- dex, among different plasma NT-proBNP levels groups was significant after onset, in three months and six months （P 〈 0.05）. Conclusion Plasma NT-proBNP can predict long-term ventrieular remodeling in patients with AMI, especially severe ventricular remodeling will happen earlier in NT-proBNP severe elevated AMI patients （〉 5 000 pg/mL）.
出处
《中国当代医药》
2012年第23期10-12,共3页
China Modern Medicine
