摘要
四妙勇安汤由金银花、玄参、当归、甘草四味药组成,原为治疗热毒型脱疽的一则古方,由于冠状动脉粥样硬化性心脏病(冠心病)和脱疽在西医理论中均属于血管病变,近年来许多医家运用四妙勇安汤治疗冠心病取得良好的疗效,认为其作用机制和抗炎、抗动脉粥样硬化、促进血管新生以及抗凝作用相关。研究证实四妙勇安汤中单味药物也有类似作用,当归可以改善冠脉血流,保护心肌细胞,减轻心肌缺血再灌注损伤,抗血小板聚集等功能;金银花具有抗炎和抗血小板聚集的作用;玄参具有改善冠脉血流,减轻心肌缺血损伤,抗血小板聚集的作用;甘草主要成分甘草酸具有降血脂与抗动脉粥样硬化作用,阻止动脉粥样硬化的形成。
Simiao Yong＇an Decoction is made of honeysuckle, figwort, angelica, and licorice. O- riginally, it is used for treatment of heat-toxin gangrene. Due to coronary heart disease and gangrene are belong to vascular disease in western theory, many physicians use Simiao Yong＇ an Decoction as a treatment of coronary heart disease and get good effects in recent years. The mechanism is though to be anti- inflammatory, anti-atherosclerosis, promote angiogenesis, and anticoagulant related. Study confirmed that the single herb in Simiao Yong＇ an Decoction has a similar effect. Angelica can improve coronary flow, protect myocardial ceils, reduce myocardial ischemia and reperfusion injury and anti-platelet aggregation. Honeysuckle has anti-inflammatory and anti-platelet aggregation. Figwort improve coronary blood flow, reduce myocardial ischemic injury, anti-plateleti aggregation. Licorice＇ s main components, licorice acid, can reduce blood lipids and prevent the formation of atherosclerosis.
出处
《环球中医药》
CAS
2012年第8期629-633,共5页
Global Traditional Chinese Medicine
基金
国家"十一五"科技重大专项重大新药创制项目(2009ZX09103-318)
