摘要
目的 探讨ICAM - 1和E -selectim在急性胆管炎肝损害中的作用。方法 应用组织学方法观察ICAM - 1和E -selectin对肝组织PMN浸润及其肝损害作用的影响。结果急性胆管炎时PMN在肝窦及肝细胞周围大量聚集 ,大鼠肝细胞变性坏死 ,动物 12小时存活率仅为 5 6 .6 %。抗ICAN - 1及E -selectin单抗预处理使肝组织PMN数量明显减少 ,肝坏死面积减少 ,动物存活率提高。结果 ICAM - 1和E -selectin在胆道感染时肝组织PMN浸润及其肝损害过程中发挥重要作用。
AimH&Methods:The effects of ICAM-1 and E-selectin on PMN accumulation in liver and hepatic damage were investigated.Results: It was found that PMN accumulated in hepatic sinusoids and around hepatocytes,necrosis of the hepatocytes took place,and only 66.6% of rats survived 12 hours after infection.Pretreatment of anti ICAM-1 and E-selectin mAb decreased the number of PMN in hepatic sinusoid and near hepattocytes,decreased necrosis of the hepatocytes,and improved survival rate of the infected rates.Conclusion: The results suggest that ICAM-1 and E-selectin play an important role in PMN accumulation and hepatic damage in acute cholangitis.
出处
《重庆医学》
CAS
CSCD
2000年第4期302-303,共2页
Chongqing medicine
