摘要
目的 :研究癌基因 bcl- 2和抑癌基因 p16在子宫内膜癌的表达及发生、发展中的作用。方法 :采用免疫组化 ABC法检测 5 8例子宫内膜癌中 bcl- 2、p16基因表达。结果 :子宫内膜癌中 bcl- 2的阳性表达率为 5 6 .9% ;p16阳性表达率为 43.1%。子宫内膜癌组织学分级 :高度分化腺癌 (G1 )、中等分化腺癌 (G2 )中 bcl- 2和 p16的阳性表达率显著高于未分化癌 (G3)的阳性表达率 (P<0 .0 1)。 bcl- 2表达阳性与阴性者的生存率统计、肌层浸润及手术分期无显著差异 ;p16表达阳性者生存率显著高于阴性者 ,p16的表达与肌层的浸润、手术分期相关 ,p16在 、 期中的表达显著高于 、 期中的表达 (P<0 .0 5 )。结论 :癌基因 bcl- 2和抑癌基因 p16可能在子宫内膜癌的发生、发展、转归方面起着重要作用。
Objective:To study the expression and the role of oncogene bcl-2 and suppressor gene p16 in the genesis and devolopment of endometrial carcinoma. Methods: bcl-2 and p16 expression were examined using immunohistory ABC in 58 specimens of endometrial carcinoma.Results:bcl-2positive expression rate was 56.9%and p16 positive expression rate was 43.1% in endometrial carcinoma. The rate of bcl-2and p16 positive expression of grade Ⅰ,Ⅱ was significantly higher than that in grade Ⅲ(P<0.01). There is no difference of survival rate, invasive muscularis and operating stage between positive expression and negative expression of bcl-2 in statistics. the survival rate of p16 positive expression was significantly higher than p16 negative expression. p16 expression is related with the invasion to muscularis and operating stage, The rate of p16 position expression of stage Ⅰ,Ⅱ was higher than that in stage Ⅲ,Ⅳ(P<0.05). Conclusion: Oncogene bcl-2 and suppressor gene p16 may play the important role in the genesis, development and prognosis of endometrial carcinoma. [
出处
《南通医学院学报》
2000年第3期231-232,共2页
ACTA Academiae Medicinae Nantong
