摘要
目的研究半边莲不同溶剂提取物的镇痛抗炎作用。方法制备半边莲水提取物和75%乙醇提取物,采用醋酸扭体实验和热板实验测定半边莲提取物镇痛作用,二甲苯致小鼠耳廓肿胀实验和10%蛋清致小鼠足跖肿胀实验测定半边莲提取物抗炎作用。结果半边莲水提取物可明显抑制醋酸所致小鼠扭体反应(P<0.01);给予半边莲水提取物和醇提取物1,2 h,小鼠热板痛阈值明显提高(P<0.05或P<0.01);半边莲提取物能抑制二甲苯所致小鼠耳廓肿胀(P<0.05或P<0.01);半边莲提取物在致炎后0.5,1,2,4 h能显著抑制10%蛋清所致小鼠足跖肿胀(P<0.05或P<0.01)。结论半边莲提取物有明显的镇痛和抗炎作用。
Objective To study analgesic and anti-inflammatory effects of different extracts from Chinese lobelia.Methods Water extract and 75% alcohol extract were obtained from Chinese lobelia.Anti-inflammatory effect of Chinese lobelia was studied by using mouse abdominal cavity capillary permeability increase test induced by acetic acid,mouse auricle swelling test induced by xylene,mouse toe swelling test induced by 10% albumen test in mice.Analgesic action of Chinese lobelia was studied by mouse aceticacid-induced twisting test and hot plate test.Results In the same dose,the water extract of Chinese lobelia significantly inhibited the twisting effect induced by acetic acid in the mice（P〈0.01）.The extracts of Chinese lobelia increased the threshold of pain in the mice significantly by hot plate test,after the treatment for 1 h or 2 h（P〈0.05,P〈0.01）.The extracts of Chinese lobelia inhibited xylene-induced mouse auricle swelling（P〈0.05）.The extracts of Chinese lobelia also significantly inhibited 10% albumen-induced mouse toe swelling,0.5 h,1 h,2 h or 4 h after the induced inflammation（P〈0.05,P〈0.01）.Conclusion Chinese lobelia has obvious analgesic and anti-inflammatory effects.
出处
《医药导报》
CAS
北大核心
2012年第8期982-985,共4页
Herald of Medicine
基金
右江民族医学院2010~2012年度普高学生科研项目(右医科字[2010]9号)
关键词
半边莲
镇痛
抗炎
Chinese lobelia
Analgesic action
Anti-inflammatiory
