摘要
目的探讨人绒毛膜促性腺激素(hCG)对实验性大鼠乳腺癌的化学预防作用。方法将未经产的50只SD雌性大鼠随机分为hCG早干预组,hCG晚干预组,他莫昔芬(TAM)组,暴露组,空白对照组,各10只,对5组的成癌情况进行对比分析。结果各组均有乳腺肿瘤发生,肉眼可见的肿瘤最大直径约1.8 cm,最小直径约0.5 cm。hCG早干预组与暴露组的成癌率比较差异有统计学意义(P<0.05),与TAM组的成癌率比较差异无统计学意义(P>0.05)。hCG晚干预组与暴露组的成癌率比较差异无统计学意义(P>0.05)。5组大鼠乳腺、乳腺终末芽苞、终末导管、泡状芽苞和Lob成熟的小叶相比差异有统计学意义(P<0.05)。结论 hCG能够有效地降低实验性大鼠的成癌率。
Objective To study human chorianic gonadochopin（hCG） on experimental rat breast cancer chemopreventian role. Methods 50 female SD rats with no birth were selected and randomly divided into early hCG intervention group, late hCG intervention group, tamoxifen（TAM） group, exposure group, and blank control group,10 in each group. Cancer formation of the 5 groups were analyzed and compared. Results Breast tumors occurred in every group, the biggest diameter of the tumor visible was about 1.8 cm, smallest was 0.5 cm. Cancer rate of early hCG intervention group and exposure group was significantly different （P 〈0.05）, but was not significantly different between early hCG intervention group and TAM group （ P 〉 0.05 ）. Cancer rate of late hCG intervention group and exposure group was not significantly different （P 〉 0.05 ）. Differences in mammary gland, mammary terminal buds, catheter, vesicular buds and matured Lob leaflets of the 5 groups were statistically significant （ P 〈 0.05 ）. Conclusion hCG can effectively reduce the cancer rate of the experimental rats.
出处
《医学综述》
2012年第15期2499-2500,共2页
Medical Recapitulate
关键词
人绒毛膜促性腺激素
实验性大鼠
乳腺癌
预防作用
Human chorionic gonadotropins
Experimental rat
Breast cancer
Prevention role
