摘要
目的:对贵州省含麻疹成分疫苗(measles containing vaccine,MCV)常规免疫首剂(MCV1)的评价指标进行分析评价,以获得接种率评价的客观指标。方法:采用多阶段随机抽样法抽取贵州省8月龄至6岁未患过麻疹的健康常住儿童作为研究对象,以麻疹IgG抗体阳性率为金标准,麻疹发病数据作为参考,评价调查接种率(inves-tigated immunization coverage rate,IIR)和估算接种率(estimated immunization coverage rate,EIR)。结果:8月龄至1岁、2～3岁和4～6岁MCV1的调查接种率分别为86.0%、90.1%和90.2%;调整后的调查接种率(adjusted investi-gation immunization coverage rate,AIIR)分别为89.8%、94.8%和95.3%,当疫苗效力(vaccine efficacy,VE)取82.9%时,疫苗效力法计算的估算接种率(EIR1)分别为59.8%、71.6%和77.9%,调整后的估算接种率(adjustedestimated immunization coverage rate,AEIR1)分别为68.2%、79.7%和86.8%;VE为95%时,EIR1分别为84.3%、90.1%和92.7%,AEIR1分别为88.6%、93.4%和96.0%;按世界卫生组织(WHO)推荐的方法计算的估算接种率(EIR2)分别为97.9%、94.5%和91.4%。各年龄组AIIR和VE=95%时的AEIR1估算的抗体阳性率与实测抗体阳性率相差0～2.4%,差异无统计学意义(P>0.05)。各年龄组AIIR、AEIR1(VE为95%)和EIR2估算的抗体阳性率与未发病人群率的相对误差较低,为7.0%～15.8%。结论:AIIR和疫苗效力法AEIR1(VE=95%)与实测基本相符,建议建立一套以AIIR和AEIR1为基础评价指标的接种率评价体系。
Objective ： To obtain an objective index of evaluating the immunization coverage rate of first dose of measles containing vaccine （ MCV1 ） by comparison of the indexes in Guizhou Province. Methods ： Multistage random sampling method was applied to draw subjects from healthy children who had no measles history and aged from 8 months to 6 years of age. The investigated immunization coverage rate （IIR） and the estimated immunization coverage rate （EIR） were evaluated according to the positive rate of measles antibody as a gold standard, and the data of incidence cases as a reference. Results：The IIR was 86.0% for the group aged from 8 months to 1 year, 90.1% for the group aged from 2 to 3 years and 90.2% for the group aged from 4 to 6 years. The adjusted estimated immunization coverage rate （AIIR） was 89.8%, 94.8% and 95.3% , respectively. Given the vaccine efficacy （VE） was 82.9% , the EIR1 was 59.8%, 71.6% and 77.9%, respectively and the AEIR1 was 68.2%, 79.7% and 86. g%, respectively; given the VE was 95%, the EIR1 was 84.3%, 90.1% and 92.7%, respectively, and the AEIR1 was 88.6%, 93.4% and 96.0% , respectively. The EIR2 was 97.9%, 94.5% and 91.4% , respectively. The relative difference was from 0 to 2.4% when compared with the estimated positive rate of AIIR and AEIR1 given the VE was 95% with the actual positive rate of measles antibody, the difference had no statistical significance （ P 〉 0. 05 ）. The relative error was low for the estimate positive rates of AIIR and EIR2 and AEIR1 （given the VE was 95% ） for the children that had not suffered from measles, the relative error varied from 7.0% to 15.8%. Conclusion： The investigated immunization coverage rate after adjustment and the AEIR1 （ VE 95% ） were in line with the actual positive rate of measles antibody, which suggests that we should set an integral evaluation system for the immunization coverage rate based on AIIR and AEIR1.
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2012年第4期617-621,共5页
Journal of Peking University:Health Sciences
关键词
麻疹疫苗
接种
评价研究
儿童
贵州
Measles vaccine
Vaccination
Evaluation studies
Child
Guizhou
