摘要
目的:探讨滤泡树突状细胞肉瘤(FDCS)的临床和病理学特征、免疫表型、诊断及其鉴别诊断。方法:对1例发生于子宫颈转移性滤泡树突状细胞肉瘤的临床表现、组织形态、免疫组化等进行分析,并复习相关文献。结果:镜下见肿瘤由卵圆形到梭形细胞组成,细胞核卵圆形或稍长,核仁较小,核分裂像极少见,细胞界限不清,似合体状,瘤细胞排列成片状和类似脑膜瘤的旋涡状。肿瘤细胞CD21(+),CD23(+),CR(+),HBME-1(+),S-100(-),HMB45(-),CgA(-),SMA(-),Desmin(-),Fascin(-),CD20(-)、CK(-)、Ki-67约15%～20%(+)。结论:滤泡树突状细胞肉瘤是一种罕见低度恶性肿瘤。诊断依赖于病理组织学及免疫组化标记,尚缺乏统一的治疗标准。
Objective： To explore the clinico-pathological feature, immuno-phenotype diagnosis and differential diagnosis of follicular dendritic cell sarcoma （FDCS）. Methods： Clinical features,histo-patholgic findings and immuno-histochemical staining were analyzed in 1 case of FDCS in cervix with a review of the related literature. Results： Microscopically, the tumor cells consisted of ovoid and spindle cells. The nuclei were ovoid or a bit long, nuclcoli small, rare mitotic figures, unclear boundaries, arranged into flake, and spiral ohape. The tumor cells were positive for CD23, CD21, HBME-land CR, but were uniformly negative for S-100, HMB45, CgA, SMA, Dcsmiu, Fascin, C D20, and CK. The Ki-67 positive index was 15% -20%. Conclusion： FDCS is a rare low-grade malignant tumor. Its pathological diagnosis depends on histo-pathology and immuno-histochemistry. Because this lacks a unified treatment standard at present,a stardard needs to be developed.
出处
《川北医学院学报》
CAS
2012年第4期372-375,共4页
Journal of North Sichuan Medical College
基金
四川省中医药管理局资助项目(237)
