摘要
糖尿病溃疡创面延迟愈合是长期困扰临床的难题，其治疗方式有限，手术虽然能解决部分问题，但疗效不稳定。部分患者受基础疾病的影响或经济条件的限制，难以承受手术。是否可通过非手术治疗来解决这一问题？有学者提出干细胞修复创面的理论，理由是骨髓间充质干细胞（BMSC）来源丰富、分离培养容易、增殖分化能力强[1]。现将近年这方面的研究进展综述如下。
The delayed healing of diabetic ulcer has been haunting the surgeons and researchers for a long time. Although we have been researching and exploring the effective therapies for many years, the progress has been limited. Bone marrow-derived mesenchymal stem cells （BMSCs） have gradually won worldwide attention for their characteristics of differentiating into tissue repair cells and secreting multiple cytokines as well as growth factors. In recent years, the role of BMSCs in the treatment of diabetic ulcer has been drawing more and more attention. This article reviewed the advancement in the research of BMSCs in promoting the healing of diabetic ulcer. Through a discussion of the treatment of diabetic ulcer, the related research in BMSCs, as well as its role in diabetic ulcer treatment, the mechanism of BMSCs in promoting healing of diabetic ulcers is discussed. We expect through further research, unified criteria for the quality of BMSCs, application approach and dosage of BMSCs could be established.
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2012年第4期291-293,共3页
Chinese Journal of Burns
基金
基金项目：国家重点基础研究发展计划（2012CB518104）
全军医学科学技术研究“十二五”计划专项课题（BWS11C061）
北京市自然科学基金（7123229、7122179）
关键词
骨髓
间质干细胞
成纤维细胞
糖
尿病溃疡
创面愈合
Bone marrow
Mesenchymal stem ceils
Fibroblasts
Diabetic ulcer
Wound healing
