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微粒子酶免疫法检测血清五项肿瘤标志物在鉴别诊断消化系统肿瘤和良性疾病中的价值 被引量:5

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摘要 目的研究血清甲胎蛋白(AFP)、癌胚抗原(CEA)、糖链抗原(CA)125、CA19-9和β2微球蛋白(β2-MG)对消化系统6种肿瘤与相应良性疾病的诊断价值。方法应用微粒子酶免疫法检测379例消化系统恶性肿瘤患者、329例相应良性疾病患者的血清AFP、CEA、CA125、CA19-9和β2-MG浓度,并进行比较研究。结果五项肿瘤标志物联合检测,阳性率大幅提升,胃癌组、结直肠癌组、胰腺癌组和胆囊癌组与相应良性疾病组间阳性率差异均有统计学意义(P<0.01),消化系统肿瘤整体阳性率从16.1%~36.9%提升到56.7%。对肿瘤和相应良性病的诊断特异性为:AFP62.3%~100.0%、CEA81.3%~100.0%、CA12550.0%~100.0%、CA19-958.2%~87.0%、β2-MG53.8%~100.0%。结论血清AFP、CEA、CA125、CA19-9和β2-MG对消化系统肿瘤与相应良性疾病的鉴别诊断有重要意义,联合检测则更提升了敏感性。
出处 《国际检验医学杂志》 CAS 2012年第12期1512-1515,共4页 International Journal of Laboratory Medicine
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参考文献15

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二级参考文献32

共引文献44

同被引文献48

  • 1李冬梅,赵秀媛,朱传金,刘美芹.M_2-PK与CEA、CA19-9、CA72-4对消化系统肿瘤诊断的比较分析[J].临床消化病杂志,2007,19(1):53-55. 被引量:8
  • 2Kim DH,Oh SJ,Oh CA,et al. The relationships be?tween perioperative CEA, CA19-9, and CA72-4 and recurrence in gastric cancer patients after curative radical gastrectomy[J].J Surg Oncol , 2011, 104( 6) : 585-591.
  • 3Sasaki N, Ishii T, Kamimura R, et al. Alpha-Ietopro?tein-producing pancreatic cancer cells possess cancer stem cell characteristics[n. Cancer Lett, 2011, 308 (2): 152-161.
  • 4Shimada K, I wase K, Aono T , et al. Carcinosarcoma of the gallbladder producing alpha-fetoprotein and mani?festing as leukocytosis with elevated serum granulo?cyte colony-stimulating factor: report of a case[J]. Surg Today,2009,39(3):241-246.
  • 5Gentile M, Cutrona G, Neri A, et al. Predictive value of beta2-micro-globulin (beta2-m) levels in chronic lymphocytic leukemia since Binet A stages[J]. Haematologica,2009, 94(6) : 887-888.
  • 6Basbug M, Arikanoglu Z, Bulbuller N, et al. Prognos?tic value of preoperative CEA and CA19-9 levels in patients with colorectal cancer[J]. Hepatogastroen?terology,2011,58(106) :400-405.
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