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表观遗传修饰在胚胎发育过程中的调控作用研究进展 被引量：9

Progress in roles of epigenetic modifications in regulating embryonic development
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摘要 表观遗传修饰是生命现象中普遍存在的一类基因调控方式,对维持哺乳动物正常生命活动至关重要。表观遗传修饰方式主要包括DNA甲基化、组蛋白乙酰化和组蛋白甲基化修饰,通常协同调控基因表达,且易受到营养和外源物等多种环境因素的影响,在胚胎正常发育中扮演重要角色。胚胎时期表观遗传修饰异常可能诱导胚胎甚至成年后多种疾病的发生。本文重点从DNA甲基化、组蛋白乙酰化和组蛋白甲基化修饰方面,综述表观遗传修饰在基因调控、胚胎发育过程中的作用及其可能的临床意义。 Epigenetic modiiicatlons, a class ot uDlqmtous gent regulation patterns e.g. gametogenesis and embryonic development, are crucial for activities of living mammals. DNA methylation, histone acetylation and histone methylation are three main forms of epigenetic modifications. Generally, they coordinately regulate gene expression and are readily affected by multiple enviromnental factors, such as nutrition and xenobiotics. Moreover, they play important roles in embryonic development. Many embryonic even adult diseases may be due to abnormal epigenetic modifications during embryogenesis. The potential clinical significance of DNA methylation, histone aeetylation and histone methylation on gene expression and embryonic development is reviewed.
作者 刘瑾 汪晖 张本坚 王婷婷 平洁
机构地区 武汉大学基础医学院药理学系
出处 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2012年第4期591-594,共4页 Chinese Journal of Pharmacology and Toxicology
基金 国家自然科学基金(30830112) 国家自然科学基金(81072709)~~
关键词 表观遗传学 胚胎发育 DNA甲基化 组蛋白修饰 基因表达 epigenetics embryonic development DNA methylation histone modifications gene expression
分类号 R321 [医药卫生—人体解剖和组织胚胎学]
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参考文献42

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同被引文献101

  • 1周喜顺,石清良,李秀华.提高婚前医学检查率 降低出生缺陷发生率[J].中国妇幼保健,2006,21(21):2914-2915. 被引量：12
  • 2Marazita ML,Lidral AC,Murray JC,et al.Genome scan,finemapping,and candidate gene analysis of non-syndromic cleft lip with or without cleft palate reveals phenotype-specific differences in linkage and association results[J].Hum Hered,2009,68:151-170.
  • 3Kuriyama M,Udagawa A,Yoshimoto S,et al.DNA methylation changes during cleft palate formation induced by retinoic acid in mice[J].Cleft Palate Craniofac J,2008,45:545-551.
  • 4Shi L,Wu J.Epigenetic regulation in mammalian preimplantation embryo development[J].Reprod Biol Endocrinol,2009,7:59.
  • 5.Portela A,Esteller M.Epigenetic modifications and human disease[J].Nat Biotechnol,2010,28:1057-1068.
  • 6Fujiwara K,Yamada T,Mishima K,et al.Morphological and immunohistochemical studies on cleft palates induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice[J].Congenit Anom,2008,48:68-73.
  • 7Wu Q,Ohsako S,Ishimura R,et al.Exposure of mouse preimplantation embryos to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the methylation status of imprinted genes H19 and Igf2[J].Biol Reprod,2004,70:1790-1797.
  • 8Grunstein M.Histone acetylation in chromatin structure and transcription[J].Nature,1997,389:349-352.
  • 9Yang XJ,Seto E.HATs and HDACs:from structure,function and regulation to novel strategies for therapy and prevention[J].Oncogene,2007,26:5310-5318.
  • 10Wang L,Sun H,Pan B,et al.Inhibition of histone acetylation by curcumin reduces alcohol-induced expression of heart development-related transcription factors in cardiac progenitor ceils[J].Biochem Biophys Res Commun,2012,424:593-596.

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中国药理学与毒理学杂志
2012年 第4期

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