摘要
目的探讨低级别上皮内瘤变(LGN)与慢性胃炎的关系,评价胃复春联合治疗逆转LGN的疗效。方法49例胃镜病理活检诊断为慢性胃炎伴LGN患者,随机分为两组,对照组(n=24)单用胃复春治疗,治疗组(n=25)采用胃复春、叶酸和阿司匹林联合治疗,疗程均为3个月,之后复查胃镜及病理活检。结果复查胃镜及活检显示,21例上皮内瘤消失仅为慢性胃炎,1例仍为慢性胃炎伴LGN;26例合并肠化生者中2例肠化生消失,29例合并萎缩者中8例萎缩消失,5例重度胃炎患者中4例转为轻中度胃炎。慢性胃炎合并LGN患者中,治疗组治疗效果值高于对照组(1.44±0.71对1.08±0.28),差异具有统计学意义(P<0.05);治疗组显效率亦高于对照组(32%对8.33%),差异具有统计学意义(P<0.05)。结论各类慢性胃炎可合并LGN。药物治疗有助于逆转LGN,且胃复春联合叶酸、阿司匹林治疗效果明显优于胃复春单药治疗。
Objective To observe the correlation of low-grade gastritis intraepithelial neoplasia （LGN） and chronic gastritis, and to evaluate the efficacy of Weifuchun therapeutic alliance. Methods Forty-nine patients with chronic gastritis combined with LGN were randomly divided into the control group （n=24） and the treatment group （n=25）. Patients in control group were administrated by Weifuchun, while patients in treatment group were administrated by Weifuchun, folacin and aspirin for 3 months. The gastroscope and biopsy were measured before and after treatment. Results Gastroscope and biopsy revealed that LGN were disappeared in 21 cases, one case was still chronic gastritis with LGN. In 26 patients with intestinal metaplasia, 2 cases of intestinal metaplasia were disappeared. In 29 patients with atrophy, 8 cases of atrophy were disappeared. In 5 cases with severe gastritis, 4 cases were converted to light to moderate gastritis. The treatment result value and effective rate of treatment group were higher than those of control group （1.44±0.71 vs 1.08±0.28, 32% vs 8.33%） in chronic gastritis patients with LGN, the difference had statistical significance （P〈0.05）. Conclusion All kinds of chronic gastritis can attribute to LGN, which can be reversed by drug therapy. While, Weifuchun therapeutic alliance is better than single Weifuchun therapy.
出处
《世界临床药物》
CAS
2012年第8期474-477,共4页
World Clinical Drug
基金
上海市黄浦区(原卢湾区)卫生局科研基金(项目编号:卢卫科1016)
关键词
低级别上皮内瘤变(LGN)
慢性胃炎
伴发疾病
胃复春
联合治疗
low-grade gastritis intraepithelial neoplasia （LGN）
chronic gastritis
concomitant disease
Weifuchun
therapeutic alliance
